Department of Gynecology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, and Institut de Recherche Expérimentale et Clinique, Pôle de Gynécologie, Université Catholique de Louvain, Brussels, Belgium.
Fertil Steril. 2012 Sep;98(3):720-5. doi: 10.1016/j.fertnstert.2012.05.017. Epub 2012 Jun 13.
To report the restoration of ovarian function and pregnancy in a woman after bilateral oophorectomy for benign disease after autotransplantation of cryopreserved ovarian cortex.
Case report.
Gynecology research unit in a university hospital.
PATIENT(S): A 28-year-old woman who underwent bilateral adnexectomy for ovarian abscesses at the age of 18 years.
INTERVENTION(S): We performed ovarian cortex autotransplantation to a peritoneal pocket in the broad ligament.
MAIN OUTCOME MEASURE(S): Restoration of ovarian activity and pregnancy.
RESULT(S): Restoration of ovarian function began at 20 weeks and was achieved 24 weeks after transplantation. After the fifth stimulation attempt, two mature oocytes were obtained and microinjected. One embryo (seven cells) was obtained and transferred, leading to a normal pregnancy. The patient delivered a healthy baby boy weighing 2,370 g at 38 weeks of gestation.
CONCLUSION(S): Ovarian cortex cryopreservation can be performed at the time of surgery for benign diseases when fertility is impaired. We report the first pregnancy to occur after ovarian tissue cryopreservation for benign ovarian pathology after bilateral oophorectomy.
报告一例因良性疾病行双侧卵巢切除术患者，在接受冷冻保存的卵巢皮质自体移植后，卵巢功能和妊娠得以恢复。
病例报告。
一家大学医院的妇科研究单位。
一名 28 岁女性，18 岁时因卵巢脓肿行双侧附件切除术。
我们将卵巢皮质自体移植到阔韧带的腹膜袋中。
卵巢功能恢复和妊娠。
卵巢功能恢复始于移植后 20 周，24 周后恢复。第五次刺激尝试后，获得了两个成熟的卵母细胞并进行了微注射。获得一个胚胎（七细胞）并进行了移植，导致正常妊娠。患者在妊娠 38 周时产下一名健康男婴，体重 2370 克。
当生育能力受损时，可以在因良性疾病行手术时进行卵巢皮质冷冻保存。我们报告了首例因双侧卵巢切除术后良性卵巢病变行卵巢组织冷冻保存后发生的妊娠。
