P 物质下调人肥大细胞高亲和力 IgE 受体 (FcepsilonRI) 的表达。
Substance P downregulates expression of the high affinity IgE receptor (FcepsilonRI) by human mast cells.
机构信息
Northwestern University Feinberg School of Medicine, Allergy-Immunology Division, 240 E Huron McGaw #M-327, Chicago, IL 60611, USA.
出版信息
J Neuroimmunol. 2010 Mar 30;220(1-2):17-24. doi: 10.1016/j.jneuroim.2009.12.006. Epub 2010 Feb 1.
Abstract
The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcepsilonRI) were characterized. SP downregulated expression of FcepsilonRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcepsilonRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress.
摘要
神经肽 P 物质（SP）对人类肥大细胞（MC）表型的影响知之甚少。本研究旨在研究 SP 对人 MC 高亲和力 IgE 受体（FcepsilonRI）表达的影响。SP 以浓度依赖的方式下调 FcepsilonRI mRNA 和蛋白的表达约 50%，该作用部分通过神经激肽-1 受体（NK1R）的参与介导，并导致 MC 激活减少。在 SP 暴露前用 IgE 致敏 MC 可保护 MC 免受 SP 介导的 FcepsilonRI 下调。SP 的释放可能会抑制 MC 对过敏原的反应，这些结果可能与神经炎症和应激有关。
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