Department of Gynecology and Obstetrics, University Hospital Ulm, University of Ulm Medical Center, Prittwitzstrasse 43, 89075 Ulm, Germany.
Breast. 2010 Apr;19(2):120-7. doi: 10.1016/j.breast.2009.12.006. Epub 2010 Feb 1.
The aim of that study was to analyze the impact of German-S3-breast cancer guideline adherence on clinical outcomes.
A retrospective study analyzed 3976 patients first diagnosed with primary breast cancer according to an S3-guideline-based model that classified patients retrospectively into groups receiving "guideline-adherent and "guideline non-adherent" therapy.
There was a significant association between treatment adherence and prolonged recurrence free and overall survival (p = 0.0001). The greater the number of violations in guideline adherence, the lower was overall survival (p = 0.0001). Advanced age at initial diagnosis was additionally associated with a reduction in guideline adherence. The percentage of guideline adherence for the therapeutic modalities BCT, mastectomy, axillary dissection and hormone therapy was greater than 80%. For chemotherapy, the percent of guideline adherence totaled 71.4%.
Therapies dispensed in adherence with guidelines may improve recurrence-free survival and overall survival in patients with breast cancer.
该研究旨在分析德国 S3 乳腺癌指南遵循情况对临床结局的影响。
一项回顾性研究分析了 3976 名首次被诊断为原发性乳腺癌的患者，这些患者根据基于 S3 指南的模型进行分类，分为接受“指南一致”和“指南不一致”治疗的患者组。
治疗的一致性与无复发生存期和总生存期的延长显著相关（p = 0.0001）。在指南遵守方面违反的次数越多，总体生存率越低（p = 0.0001）。初始诊断时的年龄越大，与指南遵守率降低相关。BCT、乳房切除术、腋窝清扫术和激素治疗的指南遵守率大于 80%。对于化疗，指南遵守率总计为 71.4%。
根据指南进行的治疗可能会改善乳腺癌患者的无复发生存期和总生存期。
