School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 2052, Australia.
Trends Endocrinol Metab. 2010 May;21(5):268-76. doi: 10.1016/j.tem.2010.01.001. Epub 2010 Feb 1.
Phosphatidylinositol 3'-kinase (PI3K) and Akt are signaling kinases involved in cell survival and proliferation. Recent evidence suggests that PI3K/Akt activates the sterol-regulatory element-binding proteins (SREBPs), master transcriptional regulators of lipid metabolism. The precise molecular mechanisms are controversial and differ between SREBP isoforms; proposed mechanisms include increased trafficking and processing of SREBP, reduced degradation, and involvement of the downstream signaling hub, mammalian target of rapamycin complex 1 (mTORC1). In this report, we explore the various mechanistic links between Akt and SREBP. We consider this relationship in diseases where Akt and lipids play crucial roles, including diabetes, viral infections and cancer, suggesting that this Akt-SREBP link provides fresh insights into human health and disease.
磷酸肌醇 3-激酶（PI3K）和 Akt 是参与细胞存活和增殖的信号转导激酶。最近的证据表明，PI3K/Akt 激活固醇调节元件结合蛋白（SREBPs），脂质代谢的主要转录调节因子。确切的分子机制存在争议，并且在 SREBP 同工型之间存在差异；提出的机制包括 SREBP 的运输和加工增加、降解减少以及下游信号枢纽哺乳动物雷帕霉素靶蛋白复合物 1（mTORC1）的参与。在本报告中，我们探讨了 Akt 和 SREBP 之间的各种机制联系。我们考虑了 Akt 和脂质在包括糖尿病、病毒感染和癌症在内的疾病中发挥关键作用的这种关系，表明这种 Akt-SREBP 联系为人类健康和疾病提供了新的见解。
