Korea Food Research Institute, Seongnam, 463-746, Republic of Korea.
Trends Endocrinol Metab. 2012 Feb;23(2):65-72. doi: 10.1016/j.tem.2011.10.004. Epub 2011 Dec 7.
Recent advances have significantly increased our understanding of how sterol regulatory element binding proteins (SREBPs) are regulated at the transcriptional and post-transcriptional levels in response to cellular signaling. The phosphatidyl inositol-3-kinase (PI3K) and SREBP pathways intersect at multiple points, and recent insights demonstrate the importance of tight regulation of the PI3K pathway for regulating SREBPs in the adaptation to fluctuating dietary calorie load in the mammalian liver. In addition, genetic and genome-wide approaches highlight new functions for SREBPs in connecting lipid metabolism with other cellular processes where lipid pathway flux affects physiologic or pathophysiologic adaptation, such as cancer, steatosis, and innate immunity. This review focuses on recent advances and new roles for mammalian SREBPs in physiology and metabolism.
近年来，人们对固醇调节元件结合蛋白（SREBPs）在细胞信号响应中如何在转录和转录后水平受到调控有了更深入的了解。磷脂酰肌醇-3-激酶（PI3K）和 SREBP 途径在多个点相交，最近的研究结果表明，PI3K 途径的严格调控对于哺乳动物肝脏适应波动的膳食热量负荷时 SREBPs 的调控非常重要。此外，遗传和全基因组方法强调了 SREBPs 在将脂质代谢与其他细胞过程联系起来的新功能，其中脂质途径通量会影响生理或病理生理适应，如癌症、脂肪变性和先天免疫。这篇综述重点介绍了哺乳动物 SREBPs 在生理和代谢中的最新进展和新作用。
