Wang Ni-sha, Ma Wen-li, Zhao Hai-quan, Wei Min, Zhang Bao, Zhang Wen-ling, Xiang Xing-yu
Institute of Genetic Engineering, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jan;30(1):92-5.
To study the global evolutionary characteristics of hemagglutinin gene HA1 of influenza H1N1 infecting different species during 2000-2009.
The target sequences were downloaded from NCBI and analyzed using bioinformatic software to construct the phylogenetic tree.
The HA1 amino acid sequences of influenza H1N1 contained four mutated antigenic sites and receptor-binding sites, and the novel influenza virus shared most of the mutated amino acid sites with swine H1N1 influenza virus.
The HA1 gene of novel influenza virus might originate from the early swine H1N1 influenza virus from North America, and in the evolutionary process, a number of important sites of HA1 gene mutated to result in the outbreak of influenza.
