Mayo Vaccine Research Group, Mayo Clinic, Rochester MN, 55905, USA.
Mayo Clin Proc. 2010 Mar;85(3):257-73. doi: 10.4065/mcp.2009.0615. Epub 2010 Jan 29.
Influenza is an important contributor to population and individual morbidity and mortality. The current influenza pandemic with novel H1N1 has highlighted the need for health care professionals to better understand the processes involved in creating influenza vaccines, both for pandemic as well as for seasonal influenza. This review presents an overview of influenza-related topics to help meet this need and includes a discussion of the burden of disease, virology, epidemiology, viral surveillance, and vaccine strain selection. We then present an overview of influenza vaccine-related topics, including vaccine production, vaccine efficacy and effectiveness, influenza vaccine misperceptions, and populations that are recommended to receive vaccination. English-language articles in PubMed published between January 1, 1970, and October 7, 2009, were searched using key words human influenza, influenza vaccines, influenza A, and influenza B.
流感是导致人群和个体发病和死亡的重要因素。当前的新型 H1N1 流感大流行凸显了医疗保健专业人员更好地理解流感疫苗研发过程的必要性，这不仅对于大流行流感，而且对于季节性流感都是如此。本综述介绍了与流感相关的主题，以帮助满足这一需求，包括疾病负担、病毒学、流行病学、病毒监测和疫苗株选择的讨论。然后，我们介绍了与流感疫苗相关的主题概述，包括疫苗生产、疫苗效力和效果、对流感疫苗的误解以及建议接种疫苗的人群。使用关键词“人流感”、“流感疫苗”、“流感 A”和“流感 B”，在 PubMed 中检索了 1970 年 1 月 1 日至 2009 年 10 月 7 日发表的英文文章。
