Department of Psychiatry, Institute of Psychiatry, King's College London, London SE5 8AF, UK.
Br J Psychiatry. 2010 Feb;196(2):109-15. doi: 10.1192/bjp.bp.108.060368.
Anecdotal and biographical reports suggest that bipolar disorder may be associated with high IQ or creativity, but evidence for any such connection is weak.
To investigate possible associations between scholastic achievement and later bipolar disorder, using prospective data, in a whole-population cohort study.
Using individual school grades from all individuals finishing compulsory schooling in Sweden between 1988 and 1997, we tested associations between scholastic achievement at age 15-16 and hospital admission for psychosis between ages 17 and 31, adjusting for potential confounders.
Individuals with excellent school performance had a nearly fourfold increased risk of later bipolar disorder compared with those with average grades (hazard ratio HR = 3.79, 95% CI 2.11-6.82). This association appeared to be confined to males. Students with the poorest grades were also at moderately increased risk of bipolar disorder (HR = 1.86, 95% CI 1.06-3.28).
These findings provide support for the hypothesis that exceptional intellectual ability is associated with bipolar disorder.
一些传闻和传记报道表明，双相情感障碍可能与高智商或创造力有关，但这种联系的证据很薄弱。
使用前瞻性数据，在全人群队列研究中，调查学业成绩与后来的双相情感障碍之间可能存在的关联。
我们利用瑞典所有在 1988 年至 1997 年期间完成义务教育的个体的个体学校成绩，测试了 15-16 岁时的学业成绩与 17-31 岁之间因精神病住院之间的关联，调整了潜在的混杂因素。
与成绩中等的个体相比，成绩优秀的个体后来患双相情感障碍的风险几乎增加了四倍（危险比 HR = 3.79，95%置信区间 2.11-6.82）。这种关联似乎仅限于男性。成绩最差的学生也存在中度增加的双相情感障碍风险（HR = 1.86，95%置信区间 1.06-3.28）。
这些发现为智力超群与双相情感障碍有关的假设提供了支持。
