School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, Jiangsu 210009, P. R. China.
Biol Pharm Bull. 2010;33(2):238-43. doi: 10.1248/bpb.33.238.
Baicalein, an extract from Scutellaria baicalensis, was evaluated for its ability to inhibit the influenza virus in vivo. Oral administration of baicalein to BALB/c mice infected with the influenza A/FM1/1/47(H1N1) virus showed significant effects in preventing death, increasing the mean time to death, inhibiting lung consolidation, and reducing the lung virus titer in a dose-dependent manner. These effects are believed to be due to baicalin, the metabolite of baicalein in the serum. At a concentration of baicalin 2 microg/ml in overlay medium, it showed significant inhibition in the plaque assay, and the mean IC(50) value of baicalin was calculated as 1.2 microg/ml in the cytopathic effect assay. Our results showed that baicalein warrants further research as a potential antiinfluenza viral agent.
黄芩素是黄芩的一种提取物，研究其在体内抑制流感病毒的能力。给感染甲型流感病毒 A/FM1/1/47（H1N1）的 BALB/c 小鼠口服黄芩素，可显著提高存活率、延长平均死亡时间、抑制肺实变，且呈剂量依赖性降低肺内病毒滴度。这种作用可能是由于黄芩素是血清中黄芩苷的代谢产物。在覆盖培养基中黄芩素浓度为 2μg/ml 时，在空斑减少试验中显示出显著的抑制作用，细胞病变效应试验中黄芩素的平均 IC50 值为 1.2μg/ml。我们的结果表明，黄芩素作为一种有希望的抗流感病毒药物值得进一步研究。
