Itoh Kunihiko, Hatakeyama Tomoaki, Kimura Tomoki, Shimoyama Tetsuya, Miyazaki Shozo, D'Emanuele Antony, Attwood David
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan.
Chem Pharm Bull (Tokyo). 2010 Feb;58(2):247-9. doi: 10.1248/cpb.58.247.
The aim of this study was to examine the effect of D-sorbitol on the gelation characteristics of methylcellulose in aqueous solution. The addition of D-sorbitol at concentrations of between 25 and 30% (w/v) to 1.0-2.0% (w/v) methylcellulose solutions reduced the gelation temperature from approximately 53 degrees Celsius to values between ambient and 37 degrees Celsius and increased the strength of the gel. The in vitro release of acetaminophen (paracetamol) from 2.0% (w/v) methylcellulose gels containing 20-30% (w/v) D-sorbitol gel was diffusion-controlled.
本研究的目的是考察D -山梨醇对甲基纤维素在水溶液中凝胶化特性的影响。向浓度为1.0 - 2.0%（w/v）的甲基纤维素溶液中添加浓度为25%至30%（w/v）的D -山梨醇，可使凝胶化温度从约53摄氏度降至环境温度至37摄氏度之间，并提高凝胶强度。对乙酰氨基酚（扑热息痛）从含有20 - 30%（w/v）D -山梨醇的2.0%（w/v）甲基纤维素凝胶中的体外释放是扩散控制的。
