Department of Anesthesiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
J Neurosurg Anesthesiol. 2010 Apr;22(2):155-7. doi: 10.1097/ANA.0b013e3181d1b0f4.
Phenylephrine was administered to increase arterial blood pressure in 6 monkeys anesthetized with isoflurane during both normocapnia (arterial partial pressure of CO2 35 to 44 mm Hg) and hypocapnia (arterial partial pressure of CO2 23 to 29 mm Hg). The doses of phenylephrine required to increase mean blood pressure to 33% and 66% above control pressure during hypocapnia [1.7+/-0.9 and 3.1+/-1.7 microg/kg/min (mean+/-SD), respectively] were significantly less than the doses required to achieve the same changes in blood pressure during normocapnia (2.4+/-0.9 and 4.9+/-2.4 microg/kg/min, respectively, P<0.05). In patients with intracranial pathology, for whom hypocapnia is frequently induced, phenylephrine dosage may need to be appropriately reduced.
在异氟烷麻醉的 6 只猴子中，在正常碳酸血症（动脉二氧化碳分压 35 至 44 毫米汞柱）和低碳酸血症（动脉二氧化碳分压 23 至 29 毫米汞柱）期间，使用苯肾上腺素来增加动脉血压。在低碳酸血症期间，需要苯肾上腺素的剂量分别增加平均血压至对照压力的 33%和 66% [分别为 1.7+/-0.9 和 3.1+/-1.7 microg/kg/min（平均值+/-标准差）]，显著低于在正常碳酸血症期间达到相同血压变化所需的剂量（分别为 2.4+/-0.9 和 4.9+/-2.4 microg/kg/min，P<0.05）。在患有颅内病理的患者中，经常会引起低碳酸血症，可能需要适当减少苯肾上腺素的剂量。
