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一名患有移植物抗宿主病(GvHD)的儿童肺部柏氏康宁汉姆菌感染采用脂质体两性霉素和泊沙康唑成功治疗的报告及文献综述

Report of a successful treatment of pulmonary Cunninghamella bertholletiae infection with liposomal amphotericin and posaconazole in a child with GvHD and review of the literature.

作者信息

Garbino Jorge, Myers Catherine, Ambrosioni Juan, Gumy-Pause Fabienne

机构信息

Division of Infectious Diseases, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland.

出版信息

J Pediatr Hematol Oncol. 2010 Mar;32(2):85-7. doi: 10.1097/MPH.0b013e3181c2bdce.

Abstract

Zygomycosis is an emerging, opportunistic fungal infection particularly affecting immunocomprised patients. We report the case of a 10-year-old girl who developed pulmonary zygomycosis because of Cunninghamella bertholletiae 1 year after undergoing bone marrow transplantation complicated with severe cutaneous and digestive graft-versus-host disease. Treatment with surgery and liposomal amphotericin B followed by posaconazole successfully treated the infection.

摘要

接合菌病是一种新出现的机会性真菌感染,尤其影响免疫功能低下的患者。我们报告一例10岁女孩的病例,该女孩在接受骨髓移植并发严重皮肤和消化道移植物抗宿主病1年后,因柏氏小克银汉霉感染而发生肺部接合菌病。手术联合脂质体两性霉素B治疗,随后使用泊沙康唑成功治愈了感染。

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