NeuroVascular Coordination Research Center, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea.
Mol Cells. 2010 Mar;29(3):223-7. doi: 10.1007/s10059-010-0043-x. Epub 2010 Jan 28.
Nerve injury induced protein 1, Ninj1 (Ninjurin1) is a cell surface protein that is induced by nerve injury and promotes axonal growth in the peripheral nervous system. However, the function of Ninj1 in the vascular system and central nervous system (CNS) is incompletely understood. Here we review recent studies that have shed further light on the role and regulation of Ninj1 in vascular remodeling and inflammation. Increasing evidence suggests that Ninj1 mediates cell communication and enhances the entry, migration, and activity of leukocytes such as monocytes and macrophages in developmental processes and inflammatory responses. Moreover, our recent studies show that Ninj1 regulates close interaction between leukocytes and vascular endothelial cells in vascular remodeling and inflamed CNS. Additionally, Ninj1 enhances the apoptosis-inducing activity of leukocytes and is cleaved by MMPs, resulting in loss of adhesion during tissue remodeling. The collective data described here show that Ninj1 is required for the entry, adhesion, activation, and movement of leukocytes during tissue remodeling and might be a potential therapeutic target to regulate the adhesion and trafficking of leukocytes in inflammation and leukocyte-mediated diseases such as multiple sclerosis, diabetic retinopathy, and neuropathy.
神经损伤诱导蛋白 1（Ninjurin1，Ninj1）是一种细胞表面蛋白，在神经损伤时被诱导产生，促进周围神经系统中的轴突生长。然而，Ninj1 在血管系统和中枢神经系统（CNS）中的功能尚不完全清楚。本文综述了最近的研究，这些研究进一步阐明了 Ninj1 在血管重塑和炎症中的作用和调节机制。越来越多的证据表明，Ninj1 介导细胞间通讯，并增强单核细胞和巨噬细胞等白细胞在发育过程和炎症反应中的进入、迁移和活性。此外，我们最近的研究表明，Ninj1 调节血管重塑和炎症性 CNS 中白细胞与血管内皮细胞之间的紧密相互作用。此外，Ninj1 增强了白细胞的凋亡诱导活性，并被 MMPs 切割，导致组织重塑过程中黏附丧失。综上所述，这些数据表明，Ninj1 是白细胞在组织重塑过程中进入、黏附、激活和迁移所必需的，可能是调节炎症和白细胞介导的疾病（如多发性硬化症、糖尿病性视网膜病变和神经病）中白细胞黏附和迁移的潜在治疗靶点。
