Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China,
Dev Neurosci. 2020;42(5-6):159-169. doi: 10.1159/000512222. Epub 2021 Mar 3.
Ninjurin1 (Ninj1) is a double-transmembrane cell surface protein that could promote nerve regeneration in the process of the peripheral nervous system injury and repairment. Nonetheless, the accurate function of Ninj1 in the central nervous system and outside the nervous system is not completely clear. According to the recent studies, we found that Ninj1 is also aberrantly expressed in various pathophysiological processes in vivo, including inflammation, tumorigenesis, and vascular, bone, and muscle homeostasis. These findings suggest that Ninj1 may play an influential role during these pathophysiological processes. Our review summarizes the diverse roles of Ninj1 in multiple pathophysiological processes inside and outside the nervous system. Ninj1 should be considered as an important and novel therapeutic target in certain diseases, such as inflammatory diseases and ischemic diseases. Our study provided a better understanding of Ninj1 in different pathophysiological processes and thereby provided the theoretical support for further research.
Ninjurin1（Ninj1）是一种双跨膜细胞表面蛋白，可在周围神经系统损伤和修复过程中促进神经再生。然而，Ninj1 在中枢神经系统和神经系统外的确切功能尚不完全清楚。根据最近的研究，我们发现 Ninj1 也在体内的各种病理生理过程中异常表达，包括炎症、肿瘤发生以及血管、骨骼和肌肉的稳态。这些发现表明 Ninj1 可能在这些病理生理过程中发挥重要作用。我们的综述总结了 Ninj1 在神经内外多种病理生理过程中的不同作用。Ninj1 应该被视为某些疾病（如炎症性疾病和缺血性疾病）的一个重要和新颖的治疗靶点。我们的研究加深了对 Ninj1 在不同病理生理过程中的理解，从而为进一步的研究提供了理论支持。
