Vercaigne Lavern M, Takla Teresa A, Raghavan J
Faculty of Pharmacy, University of Manitoba and Manitoba Renal Program, Winnipeg, Manitoba, Canada.
J Vasc Access. 2010 Jan-Mar;11(1):12-6. doi: 10.1177/112972981001100103.
To investigate the effect of a 30% ethanol/4% sodium citrate catheter locking solution on the mechanical properties of hemodialysis (HD) catheters over 36 weeks.
Twenty-one HD catheters were used in this study. Three catheters, not exposed to locking solutions, underwent mechanical testing to determine baseline properties. Nine of the remaining 18 catheters were filled with normal saline and underwent mechanical testing in groups of three at 12, 24 and 36 weeks. Similarly, nine catheters were filled with the 30% ethanol/4% sodium citrate locking solution and tested in a similar manner.
The average force required to break the catheter lumens tended to be smaller in the catheters exposed to 30% ethanol/4% sodium citrate compared to saline controls at 12 and 24 weeks; however, there were no statistically significant differences between the groups after 36 weeks of exposure. The forces required to break these HD catheters are magnitudes greater than forces generated during a typical HD session.
We conclude that the 30% ethanol/4% sodium citrate locking solution had an effect on the mechanical properties of the catheters investigated, but not to the degree that would preclude further in vivo investigation. Further studies are necessary to determine the safety and efficacy of this catheter locking solution.
研究30%乙醇/4%柠檬酸钠导管封管溶液在36周内对血液透析（HD）导管机械性能的影响。
本研究使用了21根HD导管。3根未接触封管溶液的导管进行机械测试以确定基线性能。其余18根导管中的9根填充生理盐水，并在第12、24和36周以每组3根的方式进行机械测试。同样，9根导管填充30%乙醇/4%柠檬酸钠封管溶液并以类似方式进行测试。
在第12周和24周时，与生理盐水对照组相比，暴露于30%乙醇/4%柠檬酸钠的导管中，使导管内腔破裂所需的平均力往往较小；然而，在暴露36周后，各组之间没有统计学上的显著差异。使这些HD导管破裂所需的力比典型HD治疗期间产生的力大得多。
我们得出结论，30%乙醇/4%柠檬酸钠封管溶液对所研究导管的机械性能有影响，但程度不至于排除进一步的体内研究。有必要进行进一步研究以确定这种导管封管溶液的安全性和有效性。
