School of Metallurgy and Materials, The University of Birmingham, Birmingham B15 2TT, UK.
J Biomed Mater Res B Appl Biomater. 2010 Apr;93(1):185-93. doi: 10.1002/jbm.b.31573.
Hospital-acquired infections (HAIs), a large proportion of which are derived from contact transmission, represent a massive global challenge. In this study a novel active screen plasma (ASP) alloying technology has been developed to generate highly durable antimicrobial surfaces by combining a wear-resistant S-phase with nanocrystalline silver for medical grade stainless steel. The phase constituent, microstructure, composition and surface roughness of the alloyed surfaces were fully characterized, and the surface hardness, wear resistance and antimicrobial efficiency of the treated surfaces were evaluated. Experimental results showed that the surface hardness and sliding wear resistance of medical grade 316LVM stainless steel can be effectively improved by the ASP alloying treatment; furthermore, the Ag alloyed S-phase can achieve 93% reduction in Escherichia coli (E. coli) after 6 h contact time. Therefore, the novel ASP alloying treatment can not only improve wear resistance but also confer antibacterial activity to stainless steel surfaces.
医院获得性感染（HAIs），其中很大一部分来源于接触传播，是一个巨大的全球性挑战。在这项研究中，开发了一种新型的主动屏蔽等离子（ASP）合金化技术，通过将耐磨 S 相和纳米银结合到医疗级不锈钢中，生成具有高耐久性的抗菌表面。对合金化表面的相组成、微观结构、成分和表面粗糙度进行了全面的表征，并评估了处理表面的表面硬度、耐磨性和抗菌效率。实验结果表明，ASP 合金化处理可以有效提高医疗级 316LVM 不锈钢的表面硬度和滑动耐磨性；此外，Ag 合金化 S 相在接触 6 小时后可使大肠杆菌（E. coli）减少 93%。因此，新型 ASP 合金化处理不仅可以提高耐磨性，还可以赋予不锈钢表面抗菌活性。
