†Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
§State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
ACS Appl Mater Interfaces. 2015 May 27;7(20):10785-94. doi: 10.1021/acsami.5b01310. Epub 2015 May 15.
Prevention of implant loosening and infection is crucial to orthopedic and dental surgeries. In this work, the surface of stainless steel (SS) was modified by silver-sourced plasma immersion ion implantation (Ag-PIII). Metallic silver nanoparticles with various diameters and distributions were fabricated on the SS surfaces after treatment with Ag-PIII for 0.5 and 1.5 h, respectively. The osteogenic activity and antimicrobial properties of SS before and after Ag-PIII treatment were evaluated using in vitro and in vivo tests. The results demonstrated that Ag-PIII treatment not only promoted the antibacterial activity of SS but also enhanced the osteogenic differentiation of human bone marrow stromal cells.
预防植入物松动和感染对于骨科和牙科手术至关重要。在这项工作中，通过银源等离子体浸没离子注入（Ag-PIII）对不锈钢（SS）表面进行了改性。在用 Ag-PIII 处理 0.5 和 1.5 h 后，分别在 SS 表面上制造了具有不同直径和分布的金属银纳米粒子。使用体外和体内试验评估了 SS 在 Ag-PIII 处理前后的成骨活性和抗菌性能。结果表明，Ag-PIII 处理不仅提高了 SS 的抗菌活性，而且增强了人骨髓基质细胞的成骨分化。
