Fleischer Alan B, Shalita Alan, Eichenfield Lawrence F, Abramovits William, Lucky Anne, Garrett Steven
Wake Forest University School of Medicine Medical Center, Winston-Salem, NC 27157, USA.
J Drugs Dermatol. 2010 Jan;9(1):33-40.
To evaluate the safety and efficacy of dapsone gel 5% in the treatment of acne when used in combination with adapalene gel 0.1%, benzoyl peroxide gel 4% or moisturizer.
This was a twelve-week, randomized, double-blind study. Patients aged 12 years and older (n=301) applied dapsone gel twice daily and were randomly assigned (1:1:1) to one of three additional treatments, applied once daily.
By week 12, dapsone gel combined with any of the three additional treatments reduced the mean number of inflammatory lesions. However, the authors did not detect a significant difference in the reduction of inflammatory lesions when dapsone was used in combination with adapalene gel or with benzoyl peroxide gel compared to the dapsone plus moisturizer combination group (P=0.052 for both versus moisturizer combination). Patients treated with dapsone gel combined with adapalene showed a significantly better response in reduction in non-inflammatory and total acne lesion count than those who received the moisturizer combination. Local adverse reactions in all three treatment groups were minimal and generally mild in severity.
Dapsone gel in combination with adapalene gel or benzoyl peroxide gel is safe and well tolerated for the treatment of acne vulgaris.
评估5%氨苯砜凝胶与0.1%阿达帕林凝胶、4%过氧化苯甲酰凝胶或保湿剂联合使用治疗痤疮的安全性和有效性。
这是一项为期12周的随机双盲研究。12岁及以上的患者（n = 301）每天使用两次氨苯砜凝胶，并被随机分配（1:1:1）至三种额外治疗之一，每天使用一次。
到第12周时，氨苯砜凝胶与三种额外治疗中的任何一种联合使用均减少了炎性皮损的平均数量。然而，与氨苯砜加保湿剂联合治疗组相比，作者未检测到氨苯砜与阿达帕林凝胶联合使用或与过氧化苯甲酰凝胶联合使用时在炎性皮损减少方面存在显著差异（两者与保湿剂联合治疗组相比P均为0.052）。与接受保湿剂联合治疗的患者相比，接受氨苯砜凝胶与阿达帕林联合治疗的患者在非炎性和痤疮皮损总数减少方面表现出明显更好的反应。所有三个治疗组的局部不良反应均很少，且严重程度一般较轻。
氨苯砜凝胶与阿达帕林凝胶或过氧化苯甲酰凝胶联合使用治疗寻常痤疮是安全且耐受性良好的。
