Jaffe J P, Gertner E, Miller W
Department of Internal Medicine, St. Paul-Ramsey Medical Center, Minnesota 55101.
Am J Hematol. 1991 Apr;36(4):280-1. doi: 10.1002/ajh.2830360411.
The clinical constellation of leukocytosis, thrombocytosis, and low or absent stainable neutrophil alkaline phosphatase (NAP) is considered characteristic of chronic myelogenous leukemia (CML). CML with eosinophilic differentiation (eosinophilic leukemia) is well described, and leukemia and other clonal hematologic malignancies are associated with the syndrome of eosinophilic fasciitis. We describe leukocytosis, thrombocytosis, eosinophilia, mild basophilia, and absent stainable NAP, initially suggesting the diagnosis of CML in a patient with the eosinophilia myalgia syndrome associated with L-tryptophan use, a condition resembling eosinophilic fasciitis. Cytogenetic and molecular genetic studies failed to demonstrate a clonal proliferation of eosinophils.
白细胞增多、血小板增多以及可染色的中性粒细胞碱性磷酸酶（NAP）降低或缺乏的临床症候群被认为是慢性粒细胞白血病（CML）的特征。伴有嗜酸性粒细胞分化的CML（嗜酸性粒细胞白血病）已有详细描述，并且白血病和其他克隆性血液系统恶性肿瘤与嗜酸性筋膜炎综合征相关。我们描述了一名使用L-色氨酸后出现嗜酸性粒细胞肌痛综合征的患者，其表现为白细胞增多、血小板增多、嗜酸性粒细胞增多、轻度嗜碱性粒细胞增多以及可染色NAP缺乏，最初提示为CML，该病症类似于嗜酸性筋膜炎。细胞遗传学和分子遗传学研究未能证实嗜酸性粒细胞的克隆性增殖。
