Aufy Sayeda M, Mahgoub Abeer M A, Saadi Mohamed Gamal El-Din, Adel Elmallawany Marwa
Department of Parasitology, Faculty of Medicine, Cairo University, Egypt.
J Egypt Soc Parasitol. 2009 Dec;39(3):943-50.
Toxoplasma gondii antibodies were detected in 78 patients with renal disease by ELISA. Patients were classified according to the renal status; chronic renal failure patients not on haemodialysis (G1 = 19), chronic renal failure patients on regular haemodialysis (G2 = 30), renal transplant recipient (G3 = 29) and 13 normal controls. Anti-Toxoplasma IgG & IgM antibodies were 36.8% & 10.5% in renal failure patients not on haemodialysis, 56.7% &16.7% in patients on regular haemodialysis and 69% & 24.1% in renal transplant recipients versus 23.1% & 0% in controls with statistical significant difference for Toxoplasma IgG antibodies only. Anti-Toxoplasma IgG antibodies levels of G3 were lower than that of G1. It was observed that the more the exposure to dialysis, the more the risk of toxoplasmosis. It was found that 85.71% of renal transplant recipient seropositive cases for anti-Toxoplasma IgM antibodies were detected in one year post-transplantation and 14.28% of cases after the first year of transplantation.
采用酶联免疫吸附测定法（ELISA）在78例肾病患者中检测到弓形虫抗体。根据肾脏状况对患者进行分类：未进行血液透析的慢性肾衰竭患者（G1组 = 19例）、定期进行血液透析的慢性肾衰竭患者（G2组 = 30例）、肾移植受者（G3组 = 29例）以及13名正常对照者。未进行血液透析的肾衰竭患者中抗弓形虫IgG和IgM抗体阳性率分别为36.8%和10.5%，定期进行血液透析的患者中分别为56.7%和16.7%，肾移植受者中分别为69%和24.1%，而对照者中分别为23.1%和0%，仅弓形虫IgG抗体存在统计学显著差异。G3组的抗弓形虫IgG抗体水平低于G1组。观察发现，透析暴露时间越长，患弓形虫病的风险越高。还发现，肾移植受者中抗弓形虫IgM抗体血清阳性病例的85.71%在移植后一年内检测到，14.28%在移植一年后检测到。
