Yoshihara Kosuke, Yahata Tetsuro, Kashima Katsunori, Mikami Takeaki, Tanaka Kenichi
Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University, Chuo Ward, Niigata, Japan.
J Reprod Med. 2009 Nov-Dec;54(11-12):669-74.
To examine the possible association of adiponectin (ADIPOQ), adiponectin receptor (ADIPOR1/2) gene polymorphisms with polycystic ovary syndrome (PCOS) and their influence on insulin resistance in Japanese women with PCOS.
Six single nucleotide polymorphisms (SNPs) in ADIPOQ and ADIPOR1/2 were genotyped in 59 infertile Japanese women with PCOS and 97 healthy Japanese controls. In addition, the association between the genotype and allele frequencies of these SNPs and the clinical phenotypes was analyzed in PCOS patients.
There was no significant difference in the genotype and allele frequencies of the 6 SNPs between PCOS patients and controls. In the PCOS group, women with the GG genotype of 45T > G of ADIPOQ had a significantly higher score in the homeostasis model assessment for insulin resistance, fasting blood sugar and insulin level than those with other genotypes. Furthermore, a statistically significant difference in the genotype frequency of 45T > G polymorphism was observed between PCOS subjects with insulin resistance (n = 38) and controls (p = 0.011).
The 6 SNPs of ADIPOQ and ADIPOR1/2 were not associated with a risk of PCOS. However, the 45T > G SNP in the ADIPOQ may be related to insulin resistance in Japanese women with PCOS.
研究脂联素（ADIPOQ）、脂联素受体（ADIPOR1/2）基因多态性与多囊卵巢综合征（PCOS）之间可能存在的关联，以及它们对日本PCOS女性胰岛素抵抗的影响。
对59名患有PCOS的日本不孕女性和97名健康日本对照者进行脂联素及脂联素受体1/2的6个单核苷酸多态性（SNP）基因分型。此外，分析了这些SNP的基因型和等位基因频率与PCOS患者临床表型之间的关联。
PCOS患者和对照组之间6个SNP的基因型和等位基因频率无显著差异。在PCOS组中，脂联素45T>G的GG基因型女性的胰岛素抵抗稳态模型评估、空腹血糖和胰岛素水平得分显著高于其他基因型女性。此外，在有胰岛素抵抗的PCOS受试者（n = 38）和对照组之间，观察到45T>G多态性的基因型频率存在统计学显著差异（p = 0.0l1）。
脂联素及脂联素受体1/2的6个SNP与PCOS风险无关。然而，脂联素中的45T>G SNP可能与日本PCOS女性的胰岛素抵抗有关。
