Department of Endocrinology and Metabolism, The General Hospital of Jinan Military Command, 25 Shifan Road, Jinan 250031, People's Republic of China.
Endocrine. 2012 Oct;42(2):299-306. doi: 10.1007/s12020-012-9605-3. Epub 2012 Jan 22.
Adiponectin gene polymorphisms have been implicated in polycystic ovary syndrome (PCOS) development. However, results from previous studies were inconsistent and inconclusive. To shed some light on the relationship of two adiponectin gene polymorphisms, T45G and G276T, with PCOS, we conducted the current meta-analysis. PubMed was used for searching all eligible studies up to September 30, 2011. Odds ratio (OR) with the corresponding 95% confidence interval (CI) was adopted to evaluate the strength of the associations. In total, ten case-control studies involving 2,821 participants were included in the meta-analysis. Results showed that the T45G polymorphism was not associated with PCOS for allelic contrast (OR = 1.10, 95%CI: 0.83-1.44, P = 0.514), with evidence of large heterogeneity (P(heterogeneity) = 0.002). Concerning G276T polymorphism, the results showed that the T allele was related to a reduced risk of PCOS compared with the G allele under allelic genetic model (OR = 0.81, 95%CI: 0.70-0.93, P = 0.003), and no significant heterogeneity (P(heterogeneity) = 0.268) was revealed. Similar results were observed under additive, dominant and recessive genetic models for both of these two polymorphisms. No publication bias was detected. Our results suggested that the T45G polymorphism of adiponectin gene was not significantly associated with PCOS, while the G276T polymorphism was related to a decreased risk of PCOS.
脂联素基因多态性与多囊卵巢综合征（PCOS）的发生有关。然而，先前的研究结果并不一致，也没有定论。为了阐明两种脂联素基因多态性，T45G 和 G276T，与 PCOS 的关系，我们进行了当前的荟萃分析。我们使用 PubMed 搜索了截至 2011 年 9 月 30 日的所有合格研究。采用比值比（OR）及其相应的 95%置信区间（CI）来评估关联的强度。总共纳入了 10 项病例对照研究，涉及 2821 名参与者。结果表明，T45G 多态性与 PCOS 的等位基因对比无关（OR = 1.10，95%CI：0.83-1.44，P = 0.514），存在显著的异质性（P（异质性）= 0.002）。关于 G276T 多态性，结果表明，T 等位基因与 PCOS 的风险降低有关，与 G 等位基因相比，在等位基因遗传模型下（OR = 0.81，95%CI：0.70-0.93，P = 0.003），并且没有显著的异质性（P（异质性）= 0.268）。对于这两种多态性，在加性、显性和隐性遗传模型下，也观察到了类似的结果。没有发现发表偏倚。我们的结果表明，脂联素基因的 T45G 多态性与 PCOS 无显著相关性，而 G276T 多态性与 PCOS 的风险降低有关。
