Taniyama M, Kushima K, Ban Y, Kaihara M, Nagakura H, Sekita S, Katagiri T, Sueki H
Third Dept. of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Am J Med Sci. 1991 Apr;301(4):269-71. doi: 10.1097/00000441-199104000-00009.
Alopecia areata universalis developed gradually over nine months in a 25-year-old woman. When her scalp hairs were totally lost and other body hair began to fall out, the symptoms of insulin dependent diabetes mellitus, an organ-specific autoimmune disease, developed rapidly and progressed to diabetic coma. Alopecia did not regress after the metabolic state improved following insulin therapy. Biopsy of the scalp skin revealed significant reduction of the total number of hair bulbs and prominent lymphocyte infiltration into the remaining hair follicles. Insulin dependent diabetes mellitus and alopecia areata universalis are both thought to be related to the autoimmune mechanism and sometimes coexist. However, simultaneous development of these two disorders is extremely rare.
一名25岁女性在9个月内逐渐发展为全秃。当她的头皮毛发完全脱落且其他身体毛发开始脱落时，胰岛素依赖型糖尿病（一种器官特异性自身免疫性疾病）的症状迅速出现并发展为糖尿病昏迷。胰岛素治疗后代谢状态改善，但脱发并未消退。头皮皮肤活检显示毛囊总数显著减少，剩余毛囊中有明显的淋巴细胞浸润。胰岛素依赖型糖尿病和全秃都被认为与自身免疫机制有关，有时会同时存在。然而，这两种疾病同时发生极为罕见。
