Neonatology Service, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
J Perinat Med. 2010 May;38(3):269-73. doi: 10.1515/jpm.2010.029.
To assess the relationship between maternal clinical chorioamnionitis and neonatal outcome in preterm very-low birthweight (VLBW) infants.
An observational case-control study was conducted in the Neonatology Services of 12 acute-care teaching hospitals in Spain. Between January 2004 and December 2006, all consecutive VLBW (< or =1500 g) infants born to a mother with clinical chorioamnionitis were enrolled. Controls were infants without chorioamnionitis matched by gestational age who were born immediately after each index case.
There were 165 cases and 163 controls. A significantly higher percentage of cases than controls required intubation (53% vs. 35.8%), had normal intrauterine growth (98.1% vs. 84.7%), were born in a tertiary center (inborn) (95.1% vs. 89.1%), from single gestations (76.4% vs. 65.6%) and vaginal delivery (47.3% vs. 33.3%), showed a lower Apgar score at 5 min, and presented a higher rate of early-onset sepsis (10.4% vs. 1.2%). Older maternal age (32.5 vs. 30.8 years), premature labor (67.3% vs. 25.8%), premature rupture of membranes (61.3% vs. 25.8%), and antibiotic treatment (88.5% vs. 52.3%) were significantly more frequent among cases than controls.
After controlling by gestational age, maternal chorioamnionitis was associated with neonatal depression and early sepsis but not with other prematurity-related complications.
评估母体临床绒毛膜羊膜炎与早产儿极低出生体重儿（VLBW）新生儿结局的关系。
这是一项在西班牙 12 家急性护理教学医院新生儿科进行的观察性病例对照研究。2004 年 1 月至 2006 年 12 月，连续纳入患有临床绒毛膜羊膜炎的 VLBW（<或=1500g）婴儿的母亲所生的所有婴儿。对照组为无绒毛膜羊膜炎的婴儿，按照出生时的胎龄进行匹配，每个病例均匹配一个对照组。
共纳入 165 例病例和 163 例对照组。与对照组相比，病例组需要插管的比例明显更高（53%比 35.8%），正常宫内生长的比例更高（98.1%比 84.7%），出生于三级中心（宫内）的比例更高（95.1%比 89.1%），单胎妊娠的比例更高（76.4%比 65.6%），阴道分娩的比例更高（47.3%比 33.3%），5 分钟时的 Apgar 评分较低，且早发性败血症的发生率更高（10.4%比 1.2%）。与对照组相比，病例组母亲的年龄更大（32.5 岁比 30.8 岁），早产（67.3%比 25.8%），胎膜早破（61.3%比 25.8%），以及抗生素治疗（88.5%比 52.3%）更为常见。
在按胎龄校正后，母体绒毛膜羊膜炎与新生儿窒息和早期败血症有关，但与其他与早产相关的并发症无关。
