母亲胰岛素样生长因子 1 和 2（IGF-1、IGF-2）以及 IGFBP-3 与胎龄和早产的关系。
The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.
机构信息
Rotunda Hospital, Parnell Street, Dublin 1, Ireland.
出版信息
J Perinat Med. 2010 May;38(3):255-9. doi: 10.1515/jpm.2010.019.
AIMS
To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery.
METHODS
Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery.
RESULTS
There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02).
CONCLUSION
Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.
目的
研究产前母血清中胰岛素样生长因子 1 和 2（IGF-1、IGF-2）和胰岛素样生长因子结合蛋白 3（IGFBP-3）的水平与分娩时的胎龄之间的关系。
方法
对伦敦大学教学医院的 1650 名低危白种人妇女进行前瞻性队列研究。在初诊时测量母血中的 IGF-1、IGF-2 和 IGFBP-3，并分析其与分娩时的胎龄之间的关系。
结果
母血 IGF-1 或 IGF-2 与早产（PTB）之间无显著相关性。与 32 周完成分娩相比，<32 周完成分娩的 IGFBP-3 水平明显降低（P=0.02）。
结论
在<32 周完成分娩的病例中，母体平均 IGFBP-3 水平显著降低。
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