Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong, China.
Diabet Med. 2010 Jan;27(1):54-60. doi: 10.1111/j.1464-5491.2009.02869.x.
Increased dietary fish-oil consumption is associated with a reduced risk of coronary heart events and has pronounced effects on dyslipidaemia. However, the effects of fish-oil supplement on vascular function and metabolic profile in patients with Type 2 diabetes mellitus (DM) are unclear.
In a double-blind placebo-controlled trial, we randomized 97 Type 2 DM patients without prior cardiovascular disease to fish-oil (4 g/day, n = 49) or olive-oil (with equivalent calories, as placebo, n = 48) supplements for 12 weeks. Assessment of vascular function with brachial artery flow-mediated dilation (FMD) and circulating levels of endothelial progenitor cells (EPCs), and metabolic parameters, high-sensitivity C-reactive protein (hsCRP), oxidative stress markers and renal function were examined before and after the supplement.
Despite a significant reduction in serum triglycerides (-0.47 mmol/l, P < 0.01), 12-week supplement of fish oil did not improve vascular function as determined by FMD (+0.16%, P = 0.83) and circulating EPC count (+4 cells/microl, P = 0.78). Furthermore, fish-oil supplement did not have any significant treatment effects on hsCRP, oxidative stress, low- and high-density lipoprotein and glycated haemoglobin (HbA(1c)) (all P > 0.05). In contrast, serum creatinine was lower (-4.5 micromol/l, P = 0.01) in fish-oil-treated patients as compared with control subjects.
This study demonstrated that 12 weeks of fish-oil supplement had no significant beneficial effect on vascular endothelial function, but improved renal function without changes in endothelial function, metabolic profiles, blood pressure, inflammation or oxidative stress in patients with Type 2 DM.
增加膳食鱼油的摄入量与冠心病事件风险降低有关，并且对血脂异常有显著影响。然而，鱼油补充剂对 2 型糖尿病（DM）患者的血管功能和代谢特征的影响尚不清楚。
在一项双盲安慰剂对照试验中，我们将 97 例无心血管疾病史的 2 型糖尿病患者随机分为鱼油（4 g/天，n = 49）或橄榄油（含等量卡路里，作为安慰剂，n = 48）补充剂组，进行 12 周的治疗。在补充前后，通过肱动脉血流介导的扩张（FMD）和循环内皮祖细胞（EPC）水平以及代谢参数、高敏 C 反应蛋白（hsCRP）、氧化应激标志物和肾功能评估血管功能。
尽管血清甘油三酯显著降低（-0.47 mmol/L，P < 0.01），但鱼油 12 周的补充并未改善 FMD 测定的血管功能（+0.16%，P = 0.83）和循环 EPC 计数（+4 个/微升，P = 0.78）。此外，鱼油补充对 hsCRP、氧化应激、低和高密度脂蛋白以及糖化血红蛋白（HbA1c）均无显著的治疗作用（均 P > 0.05）。相比之下，与对照组相比，鱼油治疗组的血清肌酐水平降低（-4.5 μmol/L，P = 0.01）。
本研究表明，12 周的鱼油补充对 2 型糖尿病患者的血管内皮功能没有显著的有益作用，但改善了肾功能，而对内皮功能、代谢特征、血压、炎症或氧化应激没有影响。
