Sforza Chiarella, Grandi Gaia, Pisoni Luca, Di Blasio Chiara, Gandolfini Mauro, Ferrario Virgilio F
Dipartimento di Morfologia Umana e Scienze Biomediche Città Studi, Università degli Studi di Milano, Milano, Italy.
Eur J Oral Sci. 2009 Dec;117(6):695-703. doi: 10.1111/j.1600-0722.2009.00685.x.
Moebius syndrome is a congenital facial palsy associated with the impairment of ocular abduction. The three-dimensional characteristics of the facial soft tissues of 12 male and 14 female subjects [3-52 yr of age (mean age + standard deviation: 17 + 14 yr)] were measured using a non-invasive, computerized system; facial volumes, areas, angles, and distances were computed and compared with those obtained in reference subjects of the same age and gender. When compared with reference subjects, patients with Moebius syndrome had a more prominent and hyperdivergent face in the sagittal plane, a smaller and more prominent upper facial third; a smaller middle facial width; a smaller nose; smaller mandibular volume, depth, corpus length, and ramus height; and a more posterior positioned mandible, with a less prominent chin. In conclusion, patients with Moebius syndrome had a tendency towards a skeletal Class II pattern. These morphological variations may be the combined effect of a general alteration of the motor and sensitive facial nerves, including the trigeminal nerve, and of a maldevelopment of the brainstem.
梅比厄斯综合征是一种与眼球外展功能障碍相关的先天性面瘫。使用非侵入性计算机系统测量了12名男性和14名女性受试者（年龄3至52岁，平均年龄±标准差：17±14岁）面部软组织的三维特征；计算了面部体积、面积、角度和距离，并与相同年龄和性别的参照受试者的测量结果进行比较。与参照受试者相比，梅比厄斯综合征患者在矢状面上面部更突出且过度发散，上三分之一面部更小且更突出；中面部宽度更小；鼻子更小；下颌体积、深度、体长度和升支高度更小；下颌位置更靠后，下巴不那么突出。总之，梅比厄斯综合征患者有呈现骨性II类错颌模式的倾向。这些形态学变异可能是运动和感觉性面神经（包括三叉神经）普遍改变以及脑干发育不良共同作用的结果。
