School of Medicine and Case Comprehensive Cancer Center, Case Western Reserve University, Department of Medicine, Division of Hematology and Oncology, Cleveland, OH 44106, USA.
J Am Geriatr Soc. 2009 Nov;57 Suppl 2:S250-2. doi: 10.1111/j.1532-5415.2009.02504.x.
Recent gains in life expectancy, coupled with aging as a risk factor for breast cancer, make breast cancer primarily a disease of older women. Evaluation of the biology of breast cancer according to age has suggested that estrogen receptor-positive, low-S-phase, low-tumor-grade, and human epidermal growth factor receptor 2-negative tumors are more common in older than younger women. However, this has not translated into any major survival advantage for older women with breast cancer over their younger counterparts. Several reasons, including undertreatment and underrepresentation in clinical trials, may account for this age-related disparity. In this brief review, recent practice-changing breast cancer updates of relevance to the care of older patients with breast cancer are discussed and summarized. Because the population is aging and the number of older patients with breast cancer will continue to increase, it is imperative that older patients with breast cancer be encouraged to participate in cutting edge research and that state-of-the-art oncology care be provided to this underserved population.
近年来，预期寿命有所延长，且衰老也是乳腺癌的一个风险因素，这使得乳腺癌主要成为老年女性的疾病。根据年龄评估乳腺癌生物学特性表明，与年轻女性相比，老年女性的雌激素受体阳性、低 S 期、低肿瘤分级和人表皮生长因子受体 2 阴性肿瘤更为常见。然而，这并没有为老年乳腺癌女性带来比年轻女性更大的生存优势。包括治疗不足和临床试验代表性不足在内的几个原因可能导致了这种与年龄相关的差异。在这篇简要综述中，讨论并总结了与老年乳腺癌患者护理相关的最新具有临床实践改变意义的乳腺癌更新。由于人口老龄化以及老年乳腺癌患者的数量将继续增加，因此必须鼓励老年乳腺癌患者参与前沿研究，并为这一服务不足的人群提供最先进的肿瘤学治疗。
