Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Retrovirology. 2010 Feb 1;7:7. doi: 10.1186/1742-4690-7-7.
Breast milk transmission remains a major mode of infant HIV acquisition, yet anatomic and immunologic forces shaping virus quasispecies in milk are not well characterized. In this study, phylogenic analysis of envelope sequences of milk SIV variants revealed groups of nearly identical viruses, indicating local virus production. However, comparison of the patterns and rates of CTL escape of blood and milk virus demonstrated only subtle differences between the compartments. These findings suggest that a substantial fraction of milk viruses are produced by locally-infected cells, but are shaped by cellular immune pressures similar to that in the blood.
母乳传播仍然是婴儿感染 HIV 的主要途径，但尚不清楚塑造乳汁中病毒准种的解剖和免疫因素。在这项研究中，对 SIV 变体的 envelope 序列进行系统发育分析显示，几乎相同的病毒群表明局部病毒产生。然而，对血液和乳汁病毒 CTL 逃逸模式和速率的比较表明，两个隔室之间只有细微差异。这些发现表明，大量的乳汁病毒是由局部感染的细胞产生的，但受到与血液相似的细胞免疫压力的影响。
