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在非洲绿猴母乳中，猴免疫缺陷病毒变异株的短暂分隔。

Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys.

机构信息

Human Vaccine Institute.

出版信息

J Virol. 2013 Oct;87(20):11292-9. doi: 10.1128/JVI.01643-13. Epub 2013 Aug 7.

DOI:10.1128/JVI.01643-13
PMID:23926337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3807282/
Abstract

Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.

摘要

灵长类免疫缺陷病毒（SIV）的天然宿主——绿长尾猴（AGM）通过母乳喂养传播 SIV 的情况很少见。为了在这种有限传播的情况下检测母乳 SIV 变体的遗传多样性，我们对 AGM 母乳和血浆 SIV 变体的包膜序列进行了系统发育分析。低多样性的乳病毒群与血浆病毒群相分离。然而，这种隔离是短暂的，因为乳病毒谱系并没有纵向持续存在。

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本文引用的文献

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Retrovirology. 2013 Jan 10;10:3. doi: 10.1186/1742-4690-10-3.
2
Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.传播/创始者和慢性 C 型 HIV-1 以同等效率使用 CD4 和 CCR5 受体，并且不会被阻断整合素 α4β7 所抑制。
PLoS Pathog. 2012;8(5):e1002686. doi: 10.1371/journal.ppat.1002686. Epub 2012 May 31.
3
Mucosal simian immunodeficiency virus transmission in African green monkeys: susceptibility to infection is proportional to target cell availability at mucosal sites.黏膜猴免疫缺陷病毒在非洲绿猴中的传播：感染的易感性与黏膜部位靶细胞的可及性成正比。
J Virol. 2012 Apr;86(8):4158-68. doi: 10.1128/JVI.07141-11. Epub 2012 Feb 8.
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