Schmidt M J, Thornberry J F
Arch Int Pharmacodyn Ther. 1977 Sep;229(1):42-51.
These experiments demonstrate that altering serotonin availability in vivo does not influence the interaction of norepinephrine with adenylate cyclase in vitro. Neither reducing serotonin levels (parachloroamphetamine) nor increasing the availability of serotonin by blocking its reuptake (fluoxetine) affect the norepinephrine-induced elevation of cyclic AMP in slices of the limbic forebrain of rats. However, increasing norepinephrine availability by chronic administration of desipramine, a norepinephrine reuptake inhibitor, reduces cyclic AMP synthesis in the limbic forebrain. However, it is doubtful that blockade of norepinephrine reuptake alone accounts for the reduction in receptor sensitivity produced by desipramine since chronic administration of a new norepinephrine reuptake inhibitor, nisoxetine, does not decrease cyclic AMP accumulation.
这些实验表明，在体内改变血清素的可利用性并不会影响去甲肾上腺素在体外与腺苷酸环化酶的相互作用。无论是降低血清素水平（对氯苯丙胺）还是通过阻断其再摄取来增加血清素的可利用性（氟西汀），都不会影响去甲肾上腺素诱导的大鼠边缘前脑切片中环磷酸腺苷（cAMP）的升高。然而，通过长期给予去甲丙咪嗪（一种去甲肾上腺素再摄取抑制剂）来增加去甲肾上腺素的可利用性，会降低边缘前脑中cAMP的合成。然而，仅去甲肾上腺素再摄取的阻断是否能解释去甲丙咪嗪所产生的受体敏感性降低，这一点值得怀疑，因为长期给予一种新的去甲肾上腺素再摄取抑制剂尼索西汀，并不会减少cAMP的积累。
