Department of Medicine I, University of Würzburg, Würzburg, Germany.
Endocrinol Metab Clin North Am. 2010 Mar;39(1):127-39, x. doi: 10.1016/j.ecl.2009.10.008.
Dehydroepiandrosterone (DHEA) is secreted by the zona reticularis of the adrenal cortex and is converted into potent sex steroids in peripheral target cells. As oral DHEA administration can lead to dose-dependent increases in circulating androgens, which may reach high supraphysiologic levels in women, it has been included in the list of prohibited substances by the World Anti-Doping Agency (WADA). However, evidence for an ergogenic activity of DHEA is still largely nonexistent. Randomized trials in elderly subjects with an age-dependent decrease in DHEA have provided little or no evidence for enhanced physical performance after long-term administration of DHEA, 50 mg/d, and smaller short-term studies in healthy male athletes using higher doses were completely negative. Thus the widely perceived performance-enhancing activity of DHEA is still more myth than reality. However, because studies in female athletes are still lacking, an ergogenic activity of high-dose DHEA in this population cannot be excluded but is expected to be associated with adverse events like hirsutism, acne, and alopecia.
脱氢表雄酮（DHEA）由肾上腺皮质的网状带分泌，并在周围靶细胞中转化为强效性激素。由于口服 DHEA 给药可导致循环雄激素剂量依赖性增加，而女性的雄激素水平可能会升高至超高生理水平，因此它已被世界反兴奋剂机构（WADA）列入禁用物质清单。然而，DHEA 具有增强体力活动的作用的证据仍然基本不存在。在年龄相关的 DHEA 下降的老年受试者中进行的随机试验，在长期给予 DHEA（50mg/d）后，对身体机能的提高几乎没有提供证据，而在健康男性运动员中进行的短期、高剂量研究则完全没有作用。因此，DHEA 被广泛认为具有增强体力活动的作用，这仍然更多的是一种神话，而不是现实。然而，由于女性运动员的相关研究仍然缺乏，因此不能排除高剂量 DHEA 在该人群中的增强体力活动的作用，但预计会与多毛症、痤疮和脱发等不良事件相关。
