Martin Michelle C, Giles Kristina A, Pomposelli Frank B, Hamdan Allen D, Wyers Mark C, Schermerhorn Marc L
Division of Vascular and Endovascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, 110 Francis Street, Suite 5B, Boston, MA 02215, USA.
Ann Vasc Surg. 2010 Jan;24(1):106-12. doi: 10.1016/j.avsg.2009.09.008.
We evaluated national outcomes after open repair of abdominal aortic aneurysms (AAAs) with visceral or renal bypass (VRB).
Using the National Inpatient Sample database from 1993 through 2006, AAA repairs were identified by ICD9 codes for diagnosis of intact AAA combined with a procedure of open AAA repair. VRB patients also had an aortorenal and/or mesenteric bypass or mesenteric endarterectomy. Dissections as well as thoracic and thoracoabdominal aneurysms were excluded. Demographics and comorbidities were noted. Mortality and complications were compared to infrarenal AAA (IRA) repairs without VRB. Predictors of perioperative mortality were analyzed by multivariate logistic regression.
A total of 41,166 VRB and 362,808 IRA repairs were identified. VRB repair volume decreased by 58% and IRA volume decreased by 59% from 1993 to 2006. VRB patients had higher mortality (5.8% vs. 4.4%, p < 0.001) and more complications including acute renal failure (9.5% vs. 6.0%, p < 0.001), acute mesenteric ischemia (2.0% vs. 1.2%), and bowel resection (1.1% vs. 0.8%, p < 0.01). Patients requiring a bowel resection or with acute renal failure were 10 times more likely to die within the hospital stay regardless of repair type. Independent preoperative predictors of mortality were VRB (odds ratio [OR] = 1.3, 95% confidence interval [CI] 1.2-1.5), age (OR = 1.4 per decade, 95% CI 1.4-1.5), chronic renal failure (OR = 5.5, 95% CI 4.9-6.3), congestive heart failure (OR = 7.5, 95% CI 6.1-9.3), and pulmonary disease (OR = 1.2, 95% CI 1.1-1.2).
VRB repair volume decreased per year similarly to open IRA repair volume and may be related to increasing use of endovascular therapy. Mortality after VRB is high and dependent upon age, renal failure, and congestive heart failure. Overall, VRB repair was associated with worsened outcomes; however, this study cannot conclude that avoiding such a repair will improve outcomes. This should be factored into surgical decision making for these patients.
我们评估了采用内脏或肾动脉搭桥术(VRB)进行腹主动脉瘤(AAA)开放修复后的全国性治疗结果。
利用1993年至2006年的全国住院患者样本数据库,通过国际疾病分类第九版(ICD9)编码识别AAA修复情况,该编码用于诊断完整的AAA并结合AAA开放修复手术。VRB患者还接受了主动脉 - 肾动脉和/或肠系膜搭桥术或肠系膜内膜切除术。排除夹层动脉瘤以及胸主动脉和胸腹主动脉瘤。记录人口统计学和合并症情况。将死亡率和并发症与未采用VRB的肾下AAA(IRA)修复进行比较。通过多因素逻辑回归分析围手术期死亡率的预测因素。
共识别出41,166例VRB修复和362,808例IRA修复。从1993年到2006年,VRB修复量下降了58%,IRA修复量下降了59%。VRB患者的死亡率更高(5.8%对4.4%,p<0.001),并发症更多,包括急性肾衰竭(9.5%对6.0%,p<0.001)、急性肠系膜缺血(2.0%对1.2%)和肠切除术(1.1%对0.8%,p<0.01)。无论修复类型如何,需要进行肠切除术或患有急性肾衰竭的患者在住院期间死亡的可能性要高出10倍。术前死亡率的独立预测因素为VRB(比值比[OR]=1.3,95%置信区间[CI]1.2 - 1.5)、年龄(每增加十岁OR = 1.4,95%CI 1.4 - 1.5)、慢性肾衰竭(OR = 5.5,95%CI 4.9 - 6.3)、充血性心力衰竭(OR = 7.5,95%CI 6.1 - 9.3)和肺部疾病(OR = 1.2,95%CI 1.1 - 1.2)。
VRB修复量每年的下降情况与IRA开放修复量类似,可能与血管内治疗的使用增加有关。VRB术后死亡率较高,且取决于年龄、肾衰竭和充血性心力衰竭。总体而言,VRB修复与更差的治疗结果相关;然而,本研究不能得出避免此类修复会改善治疗结果的结论。在为这些患者进行手术决策时应考虑到这一点。