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1995年至2011年间择期腹主动脉瘤修复术中未能成功挽救的趋势。

Failure to rescue trends in elective abdominal aortic aneurysm repair between 1995 and 2011.

作者信息

Ilonzo Nicole, Egorova Natalia N, McKinsey James F, Nowygrod Roman

机构信息

Division of Vascular Surgery, Columbia University, New York, NY.

Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY.

出版信息

J Vasc Surg. 2014 Dec;60(6):1473-80. doi: 10.1016/j.jvs.2014.08.106. Epub 2014 Oct 14.

Abstract

OBJECTIVE

Factors affecting mortality after abdominal aortic aneurysm (AAA) repair have been extensively studied, but little is known about the effects of the shift to endovascular aneurysm repair (EVAR) vs open repair on failure to rescue (FTR). This study examines the impact of treatment modalities on FTR for elective AAA surgery during the years 1995 to 2011.

METHODS

Data for 491,779 patients undergoing elective AAA surgery were collected from Medicare files. Patient demographics, comorbidities, hospital volume, and repair type were collected. Primary outcome was FTR: the percentage of deaths in patients who had a complication within 30 days of surgery. Data were analyzed by univariate and multivariate analysis.

RESULTS

Patients undergoing AAA surgery have become progressively more complex, with 84.96%, 89.33%, 93.76%, and 95.72% presenting with one or more comorbidities in 1995, 2000, 2005, and 2011, respectively. Despite this, overall FTR after AAA surgery was stable from 1995 to 2000 (P = .38) and decreased from 2.68% to 1.58% between 2000 and 2011 (P < .001). In addition, FTR in EVAR decreased from 1.70% to 0.58% from 2000 to 2006 (P = .03) and then stabilized at 0.88% ± 0.9% after 2007 (P = .45). Unlike for EVAR, FTR for open repair remained stable at 3.06% ± 0.17% to 2.74% ± 0.16% from 1995 to 2000 (P = .38) but increased to 4.51% ± 0.21% in 2011 (P < .001). Mortality was highest after transfusion (20.86%), prolonged ventilation (17.37%), and respiratory complications (29.78%) for all AAA surgeries. Of note, high-volume hospitals had lower FTR rates than low-volume hospitals for both open (2.73% vs 5.66%; P < .001) and endovascular (0.7% vs 1.69%; P < .001) repair. Multivariate analysis showed that high annual volume hospital status (odds ratio, 0.6; confidence interval, 0.58-0.63) and endovascular repair (odds ratio, 0.3; confidence interval, 0.28-0.31) were associated with decreased FTR.

CONCLUSIONS

The success in AAA surgery of rescuing patients from 30-day mortality after a complication is associated with increased volume of EVAR. This increased success can also be attributed to the improved FTR outcomes and complication rates when surgeries are performed at high-volume hospital centers.

摘要

目的

影响腹主动脉瘤(AAA)修复术后死亡率的因素已得到广泛研究,但对于从开放修复转向血管内动脉瘤修复(EVAR)对抢救失败(FTR)的影响知之甚少。本研究探讨了1995年至2011年间治疗方式对择期AAA手术FTR的影响。

方法

从医疗保险档案中收集了491,779例行择期AAA手术患者的数据。收集了患者的人口统计学资料、合并症、医院规模和修复类型。主要结局是FTR:术后30天内发生并发症患者的死亡百分比。数据采用单因素和多因素分析。

结果

接受AAA手术的患者日益复杂,1995年、2000年、2005年和2011年分别有84.96%、89.33%、93.76%和95.72%的患者有一种或多种合并症。尽管如此,AAA手术后的总体FTR在1995年至2000年保持稳定(P = 0.38),在2000年至2011年间从2.68%降至1.58%(P < 0.001)。此外,EVAR的FTR从2000年至2006年从1.70%降至0.58%(P = 0.03),2007年后稳定在0.88%±0.9%(P = 0.45)。与EVAR不同,开放修复的FTR在1995年至2000年保持稳定,为3.06%±0.17%至2.74%±0.16%(P = 0.38),但在2011年升至4.51%±0.21%(P < 0.001)。所有AAA手术中,输血后死亡率最高(20.86%),长时间通气后死亡率为17.37%,呼吸并发症后死亡率为29.78%。值得注意的是,无论是开放修复(2.73%对5.66%;P < 0.001)还是血管内修复(0.7%对1.69%;P < 0.001),高容量医院的FTR率均低于低容量医院。多因素分析显示,高年手术量医院状态(比值比,0.6;置信区间,0.58 - 0.63)和血管内修复(比值比,0.3;置信区间,0.28 - 0.31)与FTR降低相关。

结论

AAA手术在并发症后将患者从30天死亡率中抢救出来的成功与EVAR手术量增加有关。这种成功率的提高也可归因于在高容量医院中心进行手术时FTR结局和并发症发生率的改善。

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