Judkins Annie, Eagleton Carl
Department of Endocrinology, Wellington Hospital, Private Bag 7902, Wellington.
N Z Med J. 2006 Sep 8;119(1241):U2144.
This aim of this study was to identify the prevalence of vitamin D deficiency in pregnant women of a Wellington general practice where 10 cases of childhood rickets had been diagnosed over the past 3 years.
Ninety pregnant women were screened for vitamin D deficiency by measuring 25-hydroxy vitamin D by DiaSorin radioimmunoassay. Recruitment into the study was over a 12-month period. A second appointment was arranged for clinical review and drawing of blood for parathyroid hormone, adjusted calcium, and alkaline phosphatase.
100% of women presenting to the general practice for antenatal care consented to the study. 87% of women had 25-hydroxy vitamin D levels below 50 nmol/L. 61.2% of women had a vitamin D level below 25 nmol/L consistent with severe vitamin D deficiency. 10 women had an elevated parathyroid hormone consistent with secondary hyperparathyroidism. Only 22% of our patients were veiled, and included a diverse ethnic population, including African, Maori, European, Middle Eastern, and Polynesian women.
Vitamin D deficiency is common in young pregnant women in this general practice, and it was not only confined to veiled women or women with dark skin. This highlights the magnitude of vitamin D deficiency in the pregnant population in a New Zealand setting; this vitamin D deficiency is responsible for the re-emergence of childhood rickets.
本研究的目的是确定在惠灵顿一家普通诊所的孕妇中维生素D缺乏症的患病率，该诊所在过去3年中诊断出10例儿童佝偻病病例。
通过DiaSorin放射免疫分析法测量25-羟维生素D，对90名孕妇进行维生素D缺乏症筛查。研究招募期为12个月。安排了第二次预约进行临床检查，并采集血液检测甲状旁腺激素、校正钙和碱性磷酸酶。
到该普通诊所接受产前护理的所有女性均同意参与研究。87%的女性25-羟维生素D水平低于50 nmol/L。61.2%的女性维生素D水平低于25 nmol/L，符合严重维生素D缺乏症。10名女性甲状旁腺激素升高，符合继发性甲状旁腺功能亢进。我们的患者中只有22%戴面纱，包括不同种族的人群，如非洲、毛利、欧洲、中东和波利尼西亚女性。
在这家普通诊所，年轻孕妇中维生素D缺乏症很常见，且不仅限于戴面纱的女性或皮肤黝黑的女性。这凸显了新西兰孕妇群体中维生素D缺乏症的严重程度；这种维生素D缺乏症是儿童佝偻病再次出现的原因。
