Klinik für Strahlenheilkunde, Charité Campus Virchow-Klinikum, Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Clin Imaging. 2010 Jan-Feb;34(1):29-35. doi: 10.1016/j.clinimag.2009.03.008.
To investigate the feasibility of determining local inflammatory activity of Crohn's disease by measurement of bowel wall perfusion kinetics using contrast-enhanced magnetic resonance imaging (MRI).
Twenty-six patients with histologically proven Crohn's disease who underwent magnetic resonance (MR) enteroclysis at 1.5 T were included in this retrospective study. Over 109 s, 150 images were acquired with a fat-saturated coronal T1-weighted 2D gradient echo sequence (TR, 9 ms; TE, 1.5 ms) during intravenous contrast administration by means of a pump (Magnevist, 0.2 ml/kg, flow 3 ml/s). On each image, signal intensity was measured in a region of interest placed in an area of maximum thickening of the inflamed bowel wall. Enhancement kinetics were correlated with the endoscopically determined severity of inflammatory activity (on a scale of 0-3).
The slope of the contrast enhancement curve significantly correlated with local inflammatory activity determined by endoscopy (R=0.594, P=.007). No significant correlation was found for area under the curve and peak maximum (R=0.411, P=.08 and R=0.334, P=.15, respectively).
Determination of the perfusion kinetics of the bowel wall by MRI enables quantitative evaluation of local inflammatory activity in patients with Crohn's disease.
通过对比增强磁共振成像（MRI）测量肠壁灌注动力学，来研究确定克罗恩病局部炎症活性的可行性。
本回顾性研究纳入了 26 名经组织学证实患有克罗恩病并在 1.5T 磁共振（MR）肠造影的患者。在静脉注射造影剂（Magnevist，0.2ml/kg，流速 3ml/s）期间，使用脂肪饱和冠状 T1 加权 2D 梯度回波序列（TR，9ms；TE，1.5ms），在 109 秒内获取了 150 张图像。在每个图像上，在发炎肠壁增厚最大的区域中，通过放置感兴趣区域来测量信号强度。增强动力学与内窥镜确定的炎症活动严重程度（0-3 级）相关。
对比增强曲线的斜率与内窥镜确定的局部炎症活性显著相关（R=0.594，P=.007）。而曲线下面积和峰值最大的相关性没有统计学意义（R=0.411，P=.08 和 R=0.334，P=.15）。
通过 MRI 确定肠壁的灌注动力学，可以定量评估克罗恩病患者的局部炎症活性。
Zotero 插件