School of Medical Sciences (Biomedical Physics), University of Aberdeen, Foresterhill, Aberdeen, UK.
Nucl Med Biol. 2010 Jan;37(1):51-5. doi: 10.1016/j.nucmedbio.2009.08.007. Epub 2009 Oct 3.
Both mutant p53 and chemoresistance are poor prognostic factors in cancer. Many studies have examined the influence of these factors on fluoro-2-deoxy-D-glucose (FDG) incorporation. Whilst mutant p53 is associated with increased FDG incorporation, chemoresistance, especially when associated with P-glycoprotein, is associated with decreased FDG incorporation.
突变型 p53 和化疗耐药均为癌症的不良预后因素。许多研究已经检查了这些因素对氟代-2-脱氧-D-葡萄糖（FDG）摄取的影响。虽然突变型 p53 与 FDG 摄取增加有关，但化疗耐药性，尤其是与 P-糖蛋白相关的耐药性，与 FDG 摄取减少有关。
