Best N, Traugott F
Department of Anaesthetics, Royal North Shore Hospital, Sydney, Australia.
Anaesth Intensive Care. 1991 Feb;19(1):50-6. doi: 10.1177/0310057X9101900109.
Propofol or methohexitone was given to the same twenty patients on two separate occasions during total intravenous anaesthesia for microlaryngeal surgery. With propofol the quality of induction was superior. Fewer patients required supplementation. Heart rate and blood pressure were well controlled at levels of 110-120% baseline. There were fewer side-effects during maintenance and recovery. Patients were able to return home earlier. However, apnoea and pain on injection occurred frequently, the latter when injection was made into the dorsum of the hand. With methohexitone, apnoea, abnormal movement, nausea, vomiting, headache, restlessness and confusion were common. Cardiovascular variables were poorly maintained at levels of 170-180% baseline. The results suggest that propofol is suitable as the sole anaesthetic agent in patients undergoing microlaryngeal surgery.
在喉显微手术的全静脉麻醉期间，对同一20例患者分两次分别给予丙泊酚或甲己炔巴比妥。使用丙泊酚时诱导质量更佳。需要追加用药的患者更少。心率和血压能很好地控制在基础水平的110 - 120%。维持期和恢复期的副作用更少。患者能更早回家。然而，呼吸暂停和注射时疼痛频繁发生，后者是在将药物注射到手背部时出现。使用甲己炔巴比妥时，呼吸暂停、异常运动、恶心、呕吐、头痛、躁动和意识模糊很常见。心血管参数难以维持在基础水平的170 - 180%。结果表明丙泊酚适合作为喉显微手术患者的单一麻醉剂。
