VA Boston Healthcare System and Harvard Medical School, Laboratory of Neuroscience, Research 151-C, 940 Belmont Street, Brockton, MA 02301, USA.
Behav Brain Res. 2010 Jun 26;210(1):123-6. doi: 10.1016/j.bbr.2010.01.043. Epub 2010 Feb 1.
Intermittent hypoxia (IH), a characteristic of sleep apnea, was modeled in Fischer Brown Norway rats (10h/day for 7 days) followed by cognitive testing in an attentional set-shifting task. The ability to shift attention from one sensory modality (e.g., odor) to another (e.g., digging medium) was impaired, a finding that could not be attributed to deficits in attention, discrimination, learning, or motor performance. Instead, the deficit is likely to reflect impaired allocation of attentional resources of the working memory system.
间歇性低氧（IH）是睡眠呼吸暂停的一个特征，研究人员在费希尔·布朗·挪威大鼠中建立了该模型（每天 10 小时，持续 7 天），随后在注意力转换任务中进行认知测试。将注意力从一种感觉模式（例如，气味）转移到另一种感觉模式（例如，挖掘介质）的能力受损，但这一发现不能归因于注意力、辨别力、学习或运动表现的缺陷。相反，这种缺陷可能反映了工作记忆系统注意力资源分配受损。
