HMG修饰与核功能。
HMG modifications and nuclear function.
作者信息
Zhang Qingchun, Wang Yinsheng
机构信息
Department of Chemistry, University of California, Riverside, CA 92521-0403, USA.
出版信息
Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):28-36. doi: 10.1016/j.bbagrm.2009.11.009.
Abstract
High mobility group (HMG) proteins assume important roles in regulating chromatin dynamics, transcriptional activities of genes and other cellular processes. Post-translational modifications of HMG proteins can alter their interactions with DNA and proteins, and consequently, affect their biological activities. Although the mechanisms through which these modifications are involved in regulating biological processes in different cellular contexts are not fully understood, new insights into these modification "codes" have emerged from the increasing appreciation of the functions of these proteins. In this review, we focus on the chemical modifications of mammalian HMG proteins and highlight their roles in nuclear functions.
摘要
高迁移率族（HMG）蛋白在调节染色质动力学、基因转录活性和其他细胞过程中发挥着重要作用。HMG蛋白的翻译后修饰可以改变它们与DNA和蛋白质的相互作用，从而影响它们的生物学活性。尽管这些修饰参与调节不同细胞环境中生物过程的机制尚未完全了解，但随着对这些蛋白质功能认识的不断增加，对这些修饰“密码”有了新的见解。在这篇综述中，我们重点关注哺乳动物HMG蛋白的化学修饰，并强调它们在核功能中的作用。
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