Institute of Cytology of the Russian Academy of Sciences, Tikhoretsky Av. 4, 194064 St. Petersburg, Russia.
Int J Mol Sci. 2024 Jul 12;25(14):7656. doi: 10.3390/ijms25147656.
HMGB3 protein belongs to the group of HMGB proteins from the superfamily of nuclear proteins with high electrophoretic mobility. HMGB proteins play an active part in almost all cellular processes associated with DNA-repair, replication, recombination, and transcription-and, additionally, can act as cytokines during infectious processes, inflammatory responses, and injuries. Although the structure and functions of HMGB1 and HMGB2 proteins have been intensively studied for decades, very little attention has been paid to HMGB3 until recently. In this review, we summarize the currently available data on the molecular structure, post-translational modifications, and biological functions of HMGB3, as well as the possible role of the ubiquitin-proteasome system-dependent HMGB3 degradation in tumor development.
HMGB3 蛋白属于高迁移率族核蛋白超家族的核蛋白，具有高电泳迁移率。HMGB 蛋白在与 DNA 修复、复制、重组和转录相关的几乎所有细胞过程中发挥积极作用，此外，在感染过程、炎症反应和损伤期间还可以作为细胞因子发挥作用。尽管 HMGB1 和 HMGB2 蛋白的结构和功能已经被深入研究了几十年，但直到最近才开始关注 HMGB3。在这篇综述中，我们总结了目前关于 HMGB3 的分子结构、翻译后修饰和生物学功能的可用数据，以及泛素-蛋白酶体系统依赖性 HMGB3 降解在肿瘤发展中的可能作用。
