HMGN蛋白的发育功能。
Developmental function of HMGN proteins.
作者信息
Furusawa Takashi, Cherukuri Srujana
机构信息
Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 3122, 9000 Rockville Pike, Bethesda, MD 20892, USA.
出版信息
Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):69-73. doi: 10.1016/j.bbagrm.2009.11.011.
Abstract
High mobility group N (HMGN) proteins are the only nuclear proteins known to specifically recognize the generic structure of the 147-bp nucleosome core particle. Both in vitro and in vivo experiments demonstrate that HMGN proteins are involved in epigenetic regulation by modulating chromatin structure and levels of posttranslational modifications of nucleosomal histones. Expression of HMGN proteins is developmentally regulated, and the loss or overexpression of these proteins can lead to developmental abnormalities. This review will focus on the role and on the possible molecular mechanism whereby HMGN proteins affect cellular differentiation and development.
摘要
高迁移率族蛋白N（HMGN）是已知的唯一能特异性识别147碱基对核小体核心颗粒通用结构的核蛋白。体外和体内实验均表明，HMGN蛋白通过调节染色质结构和核小体组蛋白的翻译后修饰水平参与表观遗传调控。HMGN蛋白的表达受发育调控，这些蛋白的缺失或过表达会导致发育异常。本综述将聚焦于HMGN蛋白影响细胞分化和发育的作用及可能的分子机制。
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The nucleosomal binding protein NSBP1 is highly expressed in the placenta and modulates the expression of differentiation markers in placental Rcho-1 cells.核小体结合蛋白NSBP1在胎盘中高度表达，并调节胎盘Rcho-1细胞中分化标志物的表达。
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