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本文引用的文献

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Sequence and chromatin determinants of cell-type-specific transcription factor binding.细胞类型特异性转录因子结合的序列和染色质决定因素。
Genome Res. 2012 Sep;22(9):1723-34. doi: 10.1101/gr.127712.111.
2
ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice.ABC 转运蛋白 B1、C1 和 G2 差异调节小鼠的神经再生。
PLoS One. 2012;7(4):e35613. doi: 10.1371/journal.pone.0035613. Epub 2012 Apr 24.
3
The nucleosome binding protein HMGN1 interacts with PCNA and facilitates its binding to chromatin.核小体结合蛋白 HMGN1 与 PCNA 相互作用，并促进其与染色质结合。
Mol Cell Biol. 2012 May;32(10):1844-54. doi: 10.1128/MCB.06429-11. Epub 2012 Mar 5.
4
A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C.晚期角蛋白包膜基因 LCE3B 和 LCE3C 缺失与类风湿关节炎关联性的复制研究。
PLoS One. 2012;7(2):e32045. doi: 10.1371/journal.pone.0032045. Epub 2012 Feb 23.
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The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse.小鼠基因组数据库 (MGD)：实验室小鼠遗传学和基因组学的综合资源。
Nucleic Acids Res. 2012 Jan;40(Database issue):D881-6. doi: 10.1093/nar/gkr974. Epub 2011 Nov 10.
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The chromatin-binding protein HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) and affects the behavior of mice.染色质结合蛋白 HMGN1 调节甲基化 CpG 结合蛋白 2（MECP2）的表达，并影响小鼠的行为。
J Biol Chem. 2011 Dec 9;286(49):42051-42062. doi: 10.1074/jbc.M111.300541. Epub 2011 Oct 17.
7
Architecture of the high mobility group nucleosomal protein 2-nucleosome complex as revealed by methyl-based NMR.基于甲基的 NMR 揭示的高迁移率族核小体蛋白 2-核小体复合物的结构。
Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12283-8. doi: 10.1073/pnas.1105848108. Epub 2011 Jul 5.
8
Mutations in CEP57 cause mosaic variegated aneuploidy syndrome.CEP57 基因突变导致马赛克变异非整倍体综合征。
Nat Genet. 2011 Jun;43(6):527-9. doi: 10.1038/ng.822. Epub 2011 May 8.
9
Effects of HMGN variants on the cellular transcription profile.HMGN 变体对细胞转录谱的影响。
Nucleic Acids Res. 2011 May;39(10):4076-87. doi: 10.1093/nar/gkq1343. Epub 2011 Jan 28.
10
Genomic profiling of HMGN1 reveals an association with chromatin at regulatory regions.对 HMGN1 的基因组分析揭示了其与调控区域染色质的关联。
Mol Cell Biol. 2011 Feb;31(4):700-9. doi: 10.1128/MCB.00740-10. Epub 2010 Dec 20.

高迁移率族蛋白 N 以组织和变体特异性的方式调节细胞转录谱的保真度。

High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.

机构信息

Protein Section, Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.

出版信息

J Biol Chem. 2013 Jun 7;288(23):16690-16703. doi: 10.1074/jbc.M113.463315. Epub 2013 Apr 24.

DOI:10.1074/jbc.M113.463315
PMID:23620591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3675603/
Abstract

The nuclei of most vertebrate cells contain members of the high mobility group N (HMGN) protein family, which bind specifically to nucleosome core particles and affect chromatin structure and function, including transcription. Here, we study the biological role of this protein family by systematic analysis of phenotypes and tissue transcription profiles in mice lacking functional HMGN variants. Phenotypic analysis of Hmgn1(tm1/tm1), Hmgn3(tm1/tm1), and Hmgn5(tm1/tm1) mice and their wild type littermates with a battery of standardized tests uncovered variant-specific abnormalities. Gene expression analysis of four different tissues in each of the Hmgn(tm1/tm1) lines reveals very little overlap between genes affected by specific variants in different tissues. Pathway analysis reveals that loss of an HMGN variant subtly affects expression of numerous genes in specific biological processes. We conclude that within the biological framework of an entire organism, HMGNs modulate the fidelity of the cellular transcriptional profile in a tissue- and HMGN variant-specific manner.

摘要

大多数脊椎动物细胞的核内都含有高迁移率族蛋白 N（HMGN）蛋白家族的成员，这些蛋白与核小体核心颗粒特异性结合，影响染色质结构和功能，包括转录。在这里，我们通过对缺乏功能性 HMGN 变体的小鼠的表型和组织转录谱进行系统分析，研究了该蛋白家族的生物学作用。对 Hmgn1(tm1/tm1)、Hmgn3(tm1/tm1)和 Hmgn5(tm1/tm1)小鼠及其野生型同窝仔鼠进行了一系列标准化测试的表型分析，发现它们具有特定变体的特异性异常。对每个 Hmgn(tm1/tm1)系的四种不同组织的基因表达分析表明，不同组织中受特定变体影响的基因之间几乎没有重叠。通路分析表明，HMGN 变体的缺失以组织和 HMGN 变体特异性的方式微妙地影响许多特定生物学过程中的基因表达。我们的结论是，在整个生物体的生物学框架内，HMGNs 以组织和 HMGN 变体特异性的方式调节细胞转录谱的准确性。