Tel Aviv University, Israel.
Ann Epidemiol. 2010 Feb;20(2):136-42. doi: 10.1016/j.annepidem.2009.10.007.
In recent years, there is a growing body of evidence suggesting that statins may have anti-inflammatory effects; consequently, it was hypothesized that statins may have a preventive effect against cataract.
The study was carried out on a retrospective cohort of 180,291 new statin users in a large health organization in Israel. Study participants were followed between 1998 and 2007 for incident cataract or cataract extraction.
During the study period 27,301 cataracts were diagnosed and 6,976 cataract extractions were performed among study participants. Persistence with statins was associated significantly (P < 0.001) with a reduced risk of cataract in men and women aged 45 to 74. Men aged 45-54 with a high (>80%) proportion of follow-up days covered with statins had an adjusted hazard ratio of 0.62 (95% confidence interval: 0.54-0.72), compared with patients with low persistence with statins. In elderly patients, no relationship or a positive relationship was observed.
Persistent statin use was significantly protective for the incidence of cataract in men and women under 75 years of age.
近年来，越来越多的证据表明他汀类药物可能具有抗炎作用；因此，有人假设他汀类药物可能对白内障有预防作用。
这项研究是在以色列一个大型医疗机构的 180291 名新他汀类药物使用者的回顾性队列中进行的。研究参与者在 1998 年至 2007 年期间因白内障或白内障摘除而进行了随访。
在研究期间，诊断出 27301 例白内障，6976 例白内障摘除。男性和女性（45-74 岁）坚持使用他汀类药物与白内障风险降低显著相关（P<0.001）。45-54 岁的男性，他汀类药物覆盖率高（>80%）的患者，调整后的风险比为 0.62（95%置信区间：0.54-0.72），与他汀类药物低坚持率的患者相比。在老年患者中，未观察到相关性或正相关性。
坚持使用他汀类药物对 75 岁以下男性和女性白内障的发病率有显著的保护作用。
