Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Clin Ther. 2011 Oct;33(10):1365-70. doi: 10.1016/j.clinthera.2011.08.010. Epub 2011 Oct 2.
Statins have been widely prescribed to treat hyperlipidemia, and can be used for primary and secondary prevention of cardiovascular diseases. Several studies have shown that statins have antiinflammatory effects in addition to cholesterol-lowering properties. There is new evidence suggesting that statins have beneficial effects on patients with chronic obstructive pulmonary disease (COPD), which is characterized by a persistent inflammatory response.
The aim of this study was to determine the association between statins and COPD by using the Taiwan National Health Insurance database.
This was a nationwide population-based cohort study. A total of 6252 newly diagnosed COPD patients (median age, 64 years; 50.3% male) who received statins for hyperlipidemia treatment were identified from the 1 million sampling cohort dataset between January 2000 and December 2007. Another 12,469 newly diagnosed COPD patients (median age, 64 years; 50.3% male) who were matched for age, gender, and medication for COPD treatment, except for statin use, were enrolled as the control group. The end point of the study was hospitalization due to COPD.
During an average of 4.58 (2.36) years' follow-up period, there were 1832 patients who experienced hospitalization for COPD exacerbation (statin vs control = 508 [8.1%] vs 1324 [10.6%]; P = 0.001). Statin use was independently associated with the decreased risk of COPD hospitalization (hazard ratio, 0.66; 95% CI, 0.60-0.74; P < 0.001).
In the selected Taiwanese population, statins were associated with reduced hospitalization due to COPD in patients newly diagnosed with COPD, suggesting a potential beneficial effect of statins in patients with COPD.
他汀类药物已广泛用于治疗高脂血症，可用于心血管疾病的一级和二级预防。几项研究表明，他汀类药物除了降低胆固醇的作用外，还有抗炎作用。有新的证据表明，他汀类药物对慢性阻塞性肺疾病（COPD）患者有益，COPD 的特征是持续的炎症反应。
本研究旨在利用台湾全民健康保险数据库确定他汀类药物与 COPD 之间的关联。
这是一项全国性基于人群的队列研究。在 2000 年 1 月至 2007 年 12 月期间，从 100 万抽样队列数据集中确定了 6252 名新诊断为 COPD 的患者（中位年龄 64 岁；50.3%为男性），这些患者因高脂血症接受他汀类药物治疗。另外招募了 12469 名新诊断为 COPD 的患者（中位年龄 64 岁；50.3%为男性）作为对照组，这些患者在年龄、性别和 COPD 治疗药物方面与他汀类药物组相匹配，除了他汀类药物的使用外。研究的终点是因 COPD 住院。
在平均 4.58（2.36）年的随访期间，有 1832 名患者因 COPD 加重而住院（他汀类药物组 vs 对照组=508 [8.1%] vs 1324 [10.6%]；P=0.001）。他汀类药物的使用与 COPD 住院风险降低独立相关（风险比，0.66；95%置信区间，0.60-0.74；P<0.001）。
在选择的台湾人群中，他汀类药物与新诊断为 COPD 的患者因 COPD 住院减少相关，提示他汀类药物对 COPD 患者可能有益。
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