采用新型定制口腔内模具技术对上颌牙龈癌患者进行高剂量率近距离放射治疗。
High-dose-rate brachytherapy for patients with maxillary gingival carcinoma using a novel customized intraoral mold technique.
作者信息
Kudoh Takaharu, Ikushima Hitoshi, Kudoh Keiko, Tokuyama Reiko, Osaki Kyohsuke, Furutani Shunsuke, Kawanaka Takashi, Kubo Akiko, Nishitani Hiromu, Honda Eiichi
机构信息
Department of Oral and Maxillofacial Radiology, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Feb;109(2):e102-8. doi: 10.1016/j.tripleo.2009.10.019.
OBJECTIVE
The purpose of this study was to introduce a novel customized intraoral mold treatment for maxillary gingival carcinoma (UGC).
STUDY DESIGN
Two patients with UGC were treated as salvage therapy using this technique. The mold was designed to keep normal soft tissues adjacent to the tumor away from the radioactive source as much as possible, and it was shielded by lead. The radiation dose on the buccal mucosa and tongue was measured at the inner and outer surfaces of the intraoral mold before starting high-dose-rate brachytherapy by the remote afterloading system, and was reduced to almost one tenth.
RESULTS
The patient had no recurrence and no severe adverse effects on the normal soft tissue adjacent to the tumor until the end of the follow-up period.
CONCLUSION
High-dose-rate brachytherapy using the novel customized intraoral mold might be a treatment option of not only salvage therapy, but definitive therapy of UGC.
目的
本研究的目的是介绍一种用于上颌牙龈癌（UGC）的新型定制口腔内模具治疗方法。
研究设计
两名UGC患者采用该技术作为挽救性治疗。该模具的设计旨在使肿瘤附近的正常软组织尽可能远离放射源，并由铅进行屏蔽。在通过远程后装系统开始高剂量率近距离放射治疗之前，在口腔内模具的内表面和外表面测量颊黏膜和舌部的辐射剂量，剂量降低至几乎十分之一。
结果
直至随访期结束，患者无复发，且肿瘤附近的正常软组织未出现严重不良反应。
结论
使用新型定制口腔内模具的高剂量率近距离放射治疗可能不仅是UGC挽救性治疗的一种选择，也是确定性治疗的一种选择。
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