Institute for Digestive and Liver Diseases, Mercy Medical Center, 301 St Paul's Place, POB suite 718, Baltimore, MD 21202, USA.
Clin Liver Dis. 2010 Feb;14(1):169-76; x. doi: 10.1016/j.cld.2009.11.007.
The World Health Organization estimates that about 170 million people are infected with hepatitis C virus (HCV). Blood transfusions from unscreened donors and unsafe therapeutic procedures are the major modes of HCV transmission in the developing world, and injection drug use accounts for most newly diagnosed HCV infections in the developed countries. Acute infection with HCV leads to symptomatic hepatitis in only a minority of patients, and recent studies suggest that spontaneous clearance of virus is higher in symptomatic acute hepatitis C infection. Pooled data from various studies suggest that higher sustained viral clearance rates could be achieved with a shorter course of antiviral treatment in the early stages of chronic HCV infection. This article examines the diagnosis of acute infection and critically appraises the various treatment regimens.
世界卫生组织估计，约有 1.7 亿人感染丙型肝炎病毒（HCV）。在发展中国家，未经筛查的供血者和不安全的治疗程序是 HCV 传播的主要途径，而注射吸毒是发达国家大多数新诊断 HCV 感染的原因。急性 HCV 感染仅导致少数患者出现症状性肝炎，最近的研究表明，有症状的急性丙型肝炎感染中病毒自发清除率更高。来自不同研究的汇总数据表明，在慢性 HCV 感染的早期阶段，采用更短疗程的抗病毒治疗可以实现更高的持续病毒清除率。本文探讨了急性感染的诊断，并对各种治疗方案进行了批判性评估。
