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接受血液透析患者中乙型肝炎和丙型肝炎感染的患病率及相关危险因素:索马里的一项单中心研究

Prevalence and Risk Factors Associated with Hepatitis B and Hepatitis C Infections among Patients Undergoing Hemodialysis: A Single-Centre Study in Somalia.

作者信息

Jeele Mohamed Osman Omar, Addow Rukia Omar Barei, Adan Faduma Nur, Jimale Liban Hassan

机构信息

Mogadishu Somali Turkish Training and Research Hospital, Mogadishu, Somalia.

Jazeera University Hospital, Mogadishu, Somalia.

出版信息

Int J Nephrol. 2021 Nov 13;2021:1555775. doi: 10.1155/2021/1555775. eCollection 2021.

DOI:10.1155/2021/1555775
PMID:34812291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8605903/
Abstract

INTRODUCTION

Hemodialysis patients have the highest risk for developing hepatitis B virus (HBV) and hepatitis C virus (HCV) than the general population. There is no study available for HBV and HCV in this population in Somalia. The main objective of this study is to determine the prevalence and risk factors of HBV and HCV infections among hemodialysis patients in Somalia.

METHODS

A cross-sectional assessment of hemodialysis patients from January 2021 to June 2021 was used in this study. 220 patients were included in this study. Age, sex, duration of hemodialysis, number of hemodialysis sessions per week, history of blood transfusion, HbsAg, and anti-HCV antibodies were examined.

RESULTS

Out of the 220 patients, males were predominant (113 (51.4%)). The mean age of the participants was 52.70. The prevalence of HBV was 7.3% (16 respondents), while the prevalence of HCV was 3.2% (7 respondents). 1 respondent (0.5%) had both HBV and HCV. There is a positive correlation between the duration of hemodialysis and the prevalence of HBV and HCV ((218) = 0.298, value <0.001), blood transfusion and prevalence of HBV and HCV ((218) = 0.347, value <0.001), and the number of hemodialysis sessions per week and prevalence of HBV and HCV ((218) = 0.402, value <0.001). The regression model of the combined predictors of history of blood transfusion, duration of hemodialysis, and number of dialysis sessions per week is  = 0.25, which indicates a 25% variance in the prevalence of HBV and HCV with a significance of (3,216) = 23.67, < 0.001.

CONCLUSIONS

The prevalence of HBV and HCV among hemodialysis patients in this study was 7.3% and 3.2%, respectively. 0.5% of the respondents had both HBV and HCV. History of blood transfusion, duration of hemodialysis, and number of hemodialysis sessions per week appear to have a strong correlation with the prevalence of HBV and HCV.

摘要

引言

与普通人群相比,血液透析患者感染乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)的风险最高。索马里尚未有关于该人群HBV和HCV的研究。本研究的主要目的是确定索马里血液透析患者中HBV和HCV感染的患病率及危险因素。

方法

本研究采用横断面评估方法,对2021年1月至2021年6月的血液透析患者进行调查。本研究纳入了220名患者。对患者的年龄、性别、血液透析时长、每周血液透析次数、输血史、乙肝表面抗原(HbsAg)和抗HCV抗体进行了检查。

结果

220名患者中,男性占多数(113名(51.4%))。参与者的平均年龄为52.70岁。HBV的患病率为7.3%(16名受访者),而HCV的患病率为3.2%(7名受访者)。1名受访者(0.5%)同时感染了HBV和HCV。血液透析时长与HBV和HCV的患病率之间存在正相关((218)=0.298,p值<0.001),输血与HBV和HCV的患病率之间存在正相关((218)=0.347,p值<0.001),每周血液透析次数与HBV和HCV的患病率之间存在正相关((218)=0.402,p值<0.001)。输血史、血液透析时长和每周透析次数的联合预测因子的回归模型为=0.25,这表明HBV和HCV患病率的方差为25%,显著性为(3,216)=23.67,p<0.001。

结论

本研究中血液透析患者HBV和HCV的患病率分别为7.3%和3.2%。0.5%的受访者同时感染了HBV和HCV。输血史、血液透析时长和每周血液透析次数似乎与HBV和HCV的患病率密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd7/8605903/5f7fdaea76a8/IJN2021-1555775.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd7/8605903/5f7fdaea76a8/IJN2021-1555775.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd7/8605903/5f7fdaea76a8/IJN2021-1555775.001.jpg

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