Biozentrum, University of Basel, Klingenbergstrasse 50, 4156 Basel, Switzerland.
J Mol Cell Biol. 2010 Aug;2(4):173-5. doi: 10.1093/jmcb/mjp053. Epub 2010 Jan 31.
Mycobacterium tuberculosis is one of the most notorious killers worldwide. These pathogens have evolved to infect human beings in a so-called dormant form that is extremely difficult to treat. New work, however, suggests that mycobacterial proteasomes, multicomponent structures that protect the microbe from damaging effects of nitric oxide generated by the host, can be selectively and specifically blocked by small molecules.
结核分枝杆菌是世界上最臭名昭著的杀手之一。这些病原体已经进化到以一种所谓的休眠形式感染人类，这种形式极难治疗。然而，新的研究表明，分枝杆菌蛋白酶体（一种保护微生物免受宿主产生的一氧化氮破坏作用的多成分结构）可以被小分子选择性和特异性地阻断。
