Colin J, Malet F, Chastel C
Department of Ophthalmology, Brest University Hospital, France.
Ann Ophthalmol. 1991 Jan;23(1):28-30.
The optimal management of herpes simplex stromal keratitis and uveitis is controversial. Thirty-two patients with presumptive herpetic anterior uveitis without active corneal inflammation received 3% acyclovir ophthalmic ointment five times daily and acyclovir 200mg orally five times a day. Eight of 18 patients (44.4%) who had received corticosteroids deteriorated over the first five days of therapy; one of 14 patients (7.1%) without previous corticosteroid use worsened during this time (P less than .05). The mean healing time was similar in these two groups. These results suggest that antiviral therapy may be first-line treatment in patients with herpetic keratouveitis who have not received corticosteroids.
单纯疱疹性基质性角膜炎和葡萄膜炎的最佳治疗方法存在争议。32例疑似疱疹性前葡萄膜炎且无活动性角膜炎症的患者，每天5次使用3%阿昔洛韦眼膏，同时每天口服5次200mg阿昔洛韦。18例接受皮质类固醇治疗的患者中有8例（44.4%）在治疗的前五天病情恶化；14例未使用过皮质类固醇的患者中有1例（7.1%）在此期间病情恶化（P小于0.05）。这两组的平均愈合时间相似。这些结果表明，抗病毒治疗可能是未接受皮质类固醇治疗的疱疹性角膜葡萄膜炎患者的一线治疗方法。
